Protein Alignment l(2)37Cb and Dhx38

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001386123.1
• Gene: Dhx38 / 292007
• RGDID: 1310345
• Length: 1227
• Species: Rattus norvegicus
• Alignment Length: 960
• Identity: 388/960 - (40%)
• Similarity: 568/960 - (59%)
• Gaps: 99/960 - (10%)

  Fly     2 SGKNRKRTASSSSSGEEP--------------------------------DSEEESRLKDLQERD 34
            |.::|.|:..|.||.:.|                                |.||.......:||.
  Rat   249 STRDRDRSVRSKSSDDTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREDGEEGIAFDTEEERQ 313

  Fly    35 EFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDRDKIVPHLRLQSRRQYLEKRKDDKV 99
            ::..  .:|..||...::|     ...:|....|....||        .::.|.|:|.|:|..::
  Rat   314 QWED--DQRQADRDWYMMD-----EGYDEFHNPLAYSSED--------YVRRREQHLHKQKQKRI 363

  Fly   100 AELEADILDDEYLFDES-VLTK----REKEEREYKKQLLNIAKEHEKAREL------ERIQRYNM 153
            :.....|.:|...::.: :||.    |.:.:.::::.  |.||.|.....|      .||.....
  Rat   364 SAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEED--NAAKVHLMVHNLVPPFLDGRIVFTKQ 426

  Fly   154 PQ----------DL----KKGERSEYVEVDEFEKQPNSEQKKWEAEQLASARFH--FGAKDAKAE 202
            |:          ||    :||.::.....::.|:: .::.|.||   ||..:..  .|.|  |.|
  Rat   427 PEPVIPVKDATSDLAIIARKGSQTVRKHREQKERR-KAQHKHWE---LAGTKLGDIMGVK--KEE 485

  Fly   203 EEYELLLDD-QIDF-IQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAV 265
            |..:.:.:| ::|: .:....|..:|||     |.:.:..|:.::.|.|:.||::..:::|:..:
  Rat   486 EPDKAMTEDGKVDYRTEQKFADHMKEKS-----EASSEFAKKKSILEQRQYLPIFAVQQELLTII 545

  Fly   266 KEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEV 330
            :::.::|:.||||||||||:.|||.:.|:| |..||||||||||||||||.||:||||..||.||
  Rat   546 RDNSIVIVVGETGSGKTTQLTQYLHQDGYT-DYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEV 609

  Fly   331 GYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARF 395
            ||:||||||||:.|::||||||.|.||.|.|.||..||.:|:||||||:|:||:||||::::...
  Rat   610 GYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVAR 674

  Fly   396 RPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQP 460
            |.:|||:::|||:||:||:|||.:.|||.||||.:||||.::|.|:.||::|.....||:|.:..
  Rat   675 RSDLKLIVTSATMDADKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGA 739

  Fly   461 LGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVIL 525
            .||||:|:.||::||...:.:.:.::.| .....|.|:|:|:.||||:|||||:..|...||.|:
  Rat   740 PGDILIFMPGQEDIEVTSDQIVEHLEEL-ENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIV 803

  Fly   526 ATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRL 590
            ||||||||||:|.|::|||.|:.|...||.|.||::|.:.|||:|:||||:||||||.||:||||
  Rat   804 ATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRL 868

  Fly   591 YTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGAL 655
            ||..|||:||...|||||||.||.|.||:||:||:.||:.|.|:||||.:.::.::.||:.||||
  Rat   869 YTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGAL 933

  Fly   656 NHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTA 720
            ::.|.||..||.|.|||:||.:.|||:.|....||.|::.|.:|||| .|||||||.:...:|..
  Rat   934 DNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSV-PAIFYRPKGREEESDQI 997

  Fly   721 RKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSC 785
            |:.|.....|||:.|.||.||...:|||.||.::||..::|::.|:||.||..:|.:..:.:.||
  Rat   998 REKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASC 1062

  Fly   786 LPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLF--EELPRWVLYHELVFTSK 848
            ..:...|||...|.||:..|:|...|.|..|:......:||.||||  ...|.:::|||||.|:|
  Rat  1063 GTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTK 1127

  Fly   849 EYMRQVIEIESKWLLEVAPHYYKAKELEDS--TNKKMPKVAGRA---EMA 893
            |||:.|..::.:||.|:.|.:|..|:...|  .|::..|....|   |||
  Rat  1128 EYMQCVTAVDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMA 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	65/321 (20%)
		HrpA	251..>868	CDD:441249	315/618 (51%)
Dhx38	NP_001386123.1	PHA03307	<182..>297	CDD:223039	7/47 (15%)
		HrpA	532..>1146	CDD:441249	315/616 (51%)