Protein Alignment l(2)37Cb and Dhx37

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001099396.2
• Gene: Dhx37 / 288647
• RGDID: 1306837
• Length: 1150
• Species: Rattus norvegicus
• Alignment Length: 1046
• Identity: 302/1046 - (28%)
• Similarity: 467/1046 - (44%)
• Gaps: 259/1046 - (24%)

  Fly    39 RLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDRD----------KIVPHLRLQSRRQYLEK 93
            :|::|.:.:.|...:|   |.|.......::||.||:|          .::|..:.:..:.....
  Rat     3 KLRRRYNVKGRLQAES---RPAKGPEAPPVRLELEDKDVLKGVDASNALVLPGRKKKKTKAPPPS 64

  Fly    94 RKDDKVAELEADILDDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQRYNMPQ--- 155
            :|:.|                  .|||  ||.:..:|.|....|:.::|..|:::....:.:
  Rat    65 KKERK------------------PLTK--KERKVLQKVLEQKEKKSQRAELLQKLSEVQVSEAEM 109

  Fly   156 -------DLKKGERSEYVEVDEFEKQPN--SEQKKWEAEQLASA-----RFHFGAKDAKAEEEYE 206
                   .|..|:|..:::    |::|:  :.|.:.:...|:.|     |.....:|::|.|:.|
  Rat   110 SLFYTTAKLGTGDRMYHIK----ERKPDQPAAQGQEKVSSLSGAHRKRHRSSSTEEDSEASEDSE 170

  Fly   207 LLLDDQIDFIQALTLDGS-----------------------------REKSSSRQPELTEKE--- 239
               .:::...|..|..|:                             .|..:|..|....|.
  Rat   171 ---PEEVTADQPRTSTGADLVHPPPATSEIKSPVPTPQPPPPGTSAPPETPASAPPPALAKPAVF 232

  Fly   240 ---RKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMI 301
               .:...:.|.|..||:...::.::.||.||.::|:.|||||||||||||:|.|||::.:..:|
  Rat   233 IPVNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSII 297

  Fly   302 GCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLAS 366
            |.|:||||||::::.|||:||.:. ...|.|.||:|...::.|.:|:||||.|.:|...:..|..
  Rat   298 GVTEPRRVAAVAMSQRVAKEMNLS-HRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLK 361

  Fly   367 YSVMIIDEAHERTLHTDILFGLVKDIARFRPE----LKLLISSATLDAEKFS----AFFDDAPIF 423
            |.|:||||||||:::||||.||:..|...|.:    |||||.||||..|.|:    .|....|:.
  Rat   362 YKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTPPPVI 426

  Fly   424 RIPGRRYPVDIFYTK-APEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIET----------- 476
            ::..|::||.:.:.| .|..||...|...|.:||...|.|.||||||||.|:..
  Rat   427 KVESRQFPVTVHFNKRTPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPI 491

  Fly   477 -C---QEVLHD------RVKRLGSKIRE------------------------------------- 494
             |   ||:..|      |.|:..::.|:
  Rat   492 RCSQPQEMEEDSAEGMRRFKKSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEAL 556

  Fly   495 ------------------------LIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLT 535
                                    |.|:|:|:.|..:.||::|:|.|...|..::|||:||||||
  Rat   557 GSDLDLDLGDSEANEGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVIATNVAETSLT 621

  Fly   536 IDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHEL 600
            |..|.||:|.|..|:..::..||:.|..|..:|:|||:|||||||||.||.|:|||:: |...:.
  Rat   622 IPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSS-AVFGDF 685

  Fly   601 EDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGE----- 660
            |....|||.|..:.:.:|.:|||.|..:|:|.|..||..|.|:.|.|.|.|||||....:
  Rat   686 EQFPPPEITRRPVEDLILQMKALNIEKVINFPFPTPPSVEALIAAEELLIALGALQAPPKQERMK 750

  Fly   661 ----------LTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKII 715
                      :|.|||.|:.|||.|...|||..|:::.|....:.|.|.::|....     :::.
  Rat   751 KLQMSQLSCPITALGRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELF-----EELD 810

  Fly   716 HADTARKNFNHMHGDHLSLLQVYNQWA-------------------ETDY---STQWCYENFIQY 758
            ....:.:....:.|....:.|:...||                   ..:|   |.|:|..|.::|
  Rat   811 RPAASEEELAELKGRRTRVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRY 875

  Fly   759 RSMKRARDVREQLVGLMQRVEIDMVSCLPE----------------TVNVRKAATAGYFYHVARL 807
            ::|...|.:|.||...:..|      | ||                ...:|:...||...|:||.
  Rat   876 KAMLEIRRLRGQLTTAVNAV------C-PEAGLFLDPKMQPPTESQVTYLRQIMAAGLGDHLARR 933

  Fly   808 SKG---------GHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLL 863
            .:.         ..|||...:..|.|||:|.||.|||.:|:|.|:|.|:|.||:.|..:|.:|:.
  Rat   934 VQSEDLLDPKWKNAYKTPLLDDPVFIHPSSVLFRELPEFVVYQEIVETTKMYMKGVSTVEIQWIP 998

  Fly   864 EVAPHY 869
            .:.|.|
  Rat   999 SLLPSY 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	50/289 (17%)
		HrpA	251..>868	CDD:441249	254/769 (33%)
Dhx37	NP_001099396.2	HrpA	248..>1036	CDD:441249	256/771 (33%)