Protein Alignment l(2)37Cb and Dhx8

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001400156.1
• Gene: Dhx8 / 287727
• RGDID: 1310723
• Length: 1242
• Species: Rattus norvegicus
• Alignment Length: 1069
• Identity: 446/1069 - (41%)
• Similarity: 614/1069 - (57%)
• Gaps: 200/1069 - (18%)

  Fly     4 KNRKRTASSSSSGEEPDSEEESRLKDL---QERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEAT 65
            |.:||:.|.....:.....:..|.:|.   :|||....|.::||.||     |.....|:...:.
  Rat   172 KKKKRSRSRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDRDR-----DHKRRHRSRSRSH 231

  Fly    66 KRLKLEHEDRDKIVPHLRLQSRRQY-LEKRKD-DKVAELEADILDDEY-------------LFDE 115
            .|.:    :|.|.....|.:||.|. .:.||| :|..|...|...|::             :::.
  Rat   232 SRTR----ERAKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPAIGDIYNG 292

  Fly   116 SV--------------LTKREK-----EEREYKKQLLNIAK------------------------ 137
            .|              |.||.:     .|...:.::.|:|.
  Rat   293 KVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSM 357

  Fly   138 ---EHEKARELERIQRYNMPQDLKKGERSE-------------------YVEVDEFEKQ---PNS 177
               :.|...:|...:|.|:     .||.:|                   .||.|..|::   ..|
  Rat   358 KDVDQETGEDLNPNRRRNL-----VGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRIS 417

  Fly   178 EQKKWEAEQLASARF-------HFGAK-------DAKAEEEYEL-LLDDQIDFIQALTL------ 221
            :.:|||.:|:.:|..       .|..:       |.:.:|:.|: |::::..|::..|.
  Rat   418 DPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMS 482

  Fly   222 --------DGSREKSSSRQPELTEKERK------------------------------------- 241
                    |||..:::..|..|.::.|:
  Rat   483 PIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM 547

  Fly   242 -----------------------------RLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGET 277
                                         ::::.|.|.|||:|..||.|:.||.::|:||:.|||
  Rat   548 RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGET 612

  Fly   278 GSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSD 342
            |||||||:.|||.|||:|...| |||||||||||||||.||:||.|..||.||||:||||||||.
  Rat   613 GSGKTTQITQYLAEAGYTSRGK-IGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSP 676

  Fly   343 RTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSAT 407
            .|::||||||.|.||.|.:|||..|:::::|||||||:|||:||||:|...:.|.::||:::|||
  Rat   677 ETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSAT 741

  Fly   408 LDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQD 472
            |||.|||.:|.:||||.||||.|||:|.|||.||.||:||..::|:|||.|:|.||||||||||:
  Rat   742 LDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQE 806

  Fly   473 EIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTID 537
            ||:|..|:|::|:|.||..:.|||::|||:.|||:||.:||:|.||.:|||::||||||||||||
  Rat   807 EIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTID 871

  Fly   538 NIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELED 602
            .|.||:||||.||..:||:||::.|:|.|||:|.|.|||||||||.||||:||||..||:.|:..
  Rat   872 GIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLT 936

  Fly   603 NTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRR 667
            ..||||||.||.:.||.|||:|||||:.|||:|.||.|||:.|:||||.||||:..|.||:||||
  Rat   937 TNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRR 1001

  Fly   668 MAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHL 732
            |||||::||:.|||:.|....|||||:||.:||||.: :|||||||...||..:..|:...||||
  Rat  1002 MAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTEGDHL 1065

  Fly   733 SLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAAT 797
            :||.|||.|....:|..||||||||.||::||:|:|:|::|:|.|.::|:|||...||.|:||..
  Rat  1066 TLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAIC 1130

  Fly   798 AGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWL 862
            :|:|.:.|:......|:|:...|.|.|||:|:||...|.||:|||||.|:|||||:|..|:.:||
  Rat  1131 SGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWL 1195

  Fly   863 LEVAPHYYKAKELEDSTNKKMPKVAGRAE 891
            :|.||.::|   :.|.|.....|...|.|
  Rat  1196 VEFAPAFFK---VSDPTKLSKQKKQQRLE 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	77/441 (17%)
		HrpA	251..>868	CDD:441249	370/616 (60%)
Dhx8	NP_001400156.1	GH2-like_DHX8	25..92	CDD:409668
		S1_DHX8_helicase	287..365	CDD:240189	8/77 (10%)
		HrpA	578..>1204	CDD:441249	373/627 (59%)