DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and Dhx40

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001005873.1	Gene:	Dhx40 / 287595	RGDID:	1359618	Length:	779	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	293/716 - (40%)
Similarity:	422/716 - (58%)	Gaps:	59/716 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 REKSSSRQPELTE----------KERKRLTLDE--TRRSLPVYPFKEDLIAAVKEHQVLIIEGET 277
            |::...|..||.|          :|.|..|..|  |..:.|:...::.||.||:::..||:.|.|
  Rat    14 RQEEGERPVELQEERPSAVRIADREEKGCTSQEGGTTPTFPIQKQRKKLIQAVRDNSFLIVTGNT 78

  Fly   278 GSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSD 342
            |||||||:|:||.||||:: ..|||.||||:|||:|||.||||||...||::|||.:||:||:|.
  Rat    79 GSGKTTQLPKYLYEAGFSQ-HGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK 142

  Fly   343 RTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVK----DIARFRPE-LKLL 402
            .|.:||||||.|.:..|.:|:|..:||:|:||||||||.|||||||:|    |.:..|.| ||::
  Rat   143 ETAIKYMTDGCLLKHILGDPNLNKFSVIILDEAHERTLTTDILFGLLKKLFQDKSPNRKEHLKVV 207

  Fly   403 ISSATLDAEKFSAFFDDAPIFRIPGRRYPV-DIFYTKAPEAD-----YIDACCVSVLQIHATQPL 461
            :.|||::..|.||||.:.|||.||||.||| :.|.......|     ||.|.....:.||..:..
  Rat   208 VMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMA 272

  Fly   462 GDILVFLTGQDEIETCQEVLHDRVKRL-------GSKIRELIVIPVYANLPSDMQAKIFEPTPPN 519
            ||||||||||.|||...|:|....:.:       .:.:..|:::|.|.::.:|.|.:||.|.||.
  Rat   273 GDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPG 337

  Fly   520 ARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAP 584
            .||.:::|||:.||||||.|.||:|.||.||.|.|.|.|::.|.||||||:.|.||:|||||||.
  Rat   338 IRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTAS 402

  Fly   585 GKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQL 649
            |||||:|:...:...:.|:.:|||:|.:|.:.||.||.|.|:|:|.|.:||||....::.||:||
  Rat   403 GKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQL 467

  Fly   650 YALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKI 714
            |...|::..|.:|:||..|.|||:.|.:...::.:....|.:.::.|||||||.: :|.||.|..
  Rat   468 YQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIRAASLDCEDLLLPIAAMLSVEN-VFIRPVDPE 531

  Fly   715 IHADTARKN---------FNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQ 770
            ...:..:|:         ||    |..:|..::.|...:.....||.:::|.:|.:..|..|..|
  Rat   532 YQKEAEQKHRELAAKAGGFN----DFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQ 592

  Fly   771 LVGLMQRVEIDMVSCLP-ETVN------VRKAATAGYFYHVARLSKGGHYKTIK-HNQTVMIHPN 827
            |..|:::::  ..|..| ||..      :|:...||||.:|||.|.|..:.|:. ....|.|||:
  Rat   593 LRELIRKLK--QQSDFPRETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPS 655

  Fly   828 SSLFEELPR--WVLYHELVFTSKEYMRQVIEIESKWLLEVAP--HYYKAKELEDSTNKKMPKVAG 888
            |:|.|:..:  |:::||::.|:|.|.|.|..|..:|:.::.|  |...|.:|.....::|...|.
  Rat   656 SALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHELNAHDLSSVARREMRDDAR 720

  Fly   889 R 889
            |
  Rat   721 R 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	286/690 (41%)
		DEXDc	269..408	CDD:238005	84/143 (59%)
		HELICc	491..581	CDD:197757	46/89 (52%)
		HA2	651..735	CDD:214852	26/92 (28%)
		OB_NTP_bind	770..869	CDD:285018	36/110 (33%)
Dhx40	NP_001005873.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		10/38 (26%)
		HrpA	51..750	CDD:224557	283/679 (42%)
		DEAH box	173..176		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820