DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and prp22

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_593253.1	Gene:	prp22 / 2542978	PomBaseID:	SPAC10F6.02c	Length:	1168	Species:	Schizosaccharomyces pombe

Alignment Length:	916	Identity:	401/916 - (43%)
Similarity:	560/916 - (61%)	Gaps:	103/916 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRTASSSSSGEEPDSEEESRLKDLQERDEFASRLKKR---------------------------D 44
            :.|...|.:...|.|.:.|.:..:...:.|.|..:||                           |
pombe   297 RSTKKGSGANAIPLSAQNSEIGHVNPLETFTSNGRKRLTSPEIWELQQLAASGAISATDIPELND 361

  Fly    45 DDRTRNVVDSTGGRRAIEEATKRLKLEHEDRDKIVPHLRLQSRRQYLE--KRKDDKV--AELEAD 105
            ...|.|..:.    ...::....::|..|:...:....::..:...::  |..|..:  |.::..
pombe   362 GFNTNNAAEI----NPEDDEDVEIELREEEPGFLAGQTKVSLKLSPIKVVKAPDGSLSRAAMQGQ 422

  Fly   106 ILDDEYLFDESVLTKRE---KEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVE 167
            ||.:    |...:.::|   |.|:|.:||.|:::.:...:...:|    ...||::
pombe   423 ILAN----DRREIRQKEAKLKSEQEMEKQDLSLSWQDTMSNPQDR----KFAQDVR--------- 470

  Fly   168 VDEFEKQPNSEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQ 232
             |...:|..||...|                                            :.::|.
pombe   471 -DSAARQLTSETPSW--------------------------------------------RQATRN 490

  Fly   233 PELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKD 297
            ..::..:|..|::.|.|..|||:..::..:.||.::|:|::.||||||||||:.|||.|.|:|.|
pombe   491 ANISYGKRTTLSMKEQREGLPVFKLRKQFLEAVSKNQILVLLGETGSGKTTQITQYLAEEGYTSD 555

  Fly   298 KKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEP 362
            .|||||||||||||||||.|||||:|.::|.||||:|||||.||..|.:||||||.|.||.|.:|
pombe   556 SKMIGCTQPRRVAAMSVAKRVAEEVGCRVGEEVGYTIRFEDKTSRMTQIKYMTDGMLQRECLVDP 620

  Fly   363 DLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPG 427
            .|:.|||:|:|||||||:.||:||||:|.....||:|||:::|||||||:||::|...|||.|||
pombe   621 LLSKYSVIILDEAHERTVATDVLFGLLKGTVLKRPDLKLIVTSATLDAERFSSYFYKCPIFTIPG 685

  Fly   428 RRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKI 492
            |.|||:|.|||.|||||:||..::|:|||.::..||||||||||:||:|..|:|::|.|.||..|
pombe   686 RSYPVEIMYTKQPEADYLDAALMTVMQIHLSEGPGDILVFLTGQEEIDTSCEILYERSKMLGDSI 750

  Fly   493 RELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRT 557
            .||:::|||:.|||::|::||||.||..|||::||||||||||||.|.||:||||.||:.|:.:.
pombe   751 PELVILPVYSALPSEIQSRIFEPAPPGGRKVVIATNIAETSLTIDGIYYVVDPGFVKQSCFDPKL 815

  Fly   558 GMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKA 622
            ||:||:|.|||:|.|.||:||||||.||||:||||..||::|:..:.:|||||.||.:.:|||||
pombe   816 GMDSLIVTPISQAQARQRSGRAGRTGPGKCYRLYTESAYRNEMLPSPIPEIQRQNLSHTILMLKA 880

  Fly   623 LGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKY 687
            :|||||::|||:||||.:|::.||:.||||.||:..|.||.|||:||:||::|.:.|:|:.|.:.
pombe   881 MGINDLLNFDFMDPPPAQTMIAALQNLYALSALDDEGLLTPLGRKMADFPMEPQLSKVLITSVEL 945

  Fly   688 KCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCY 752
            .|||||::|.|||||.: |:.||::|...||..|..|.:...|||:||.||..|.....|..|||
pombe   946 GCSEEMLSIIAMLSVPN-IWSRPREKQQEADRQRAQFANPESDHLTLLNVYTTWKMNRCSDNWCY 1009

  Fly   753 ENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVA-RLSKGGHYKTI 816
            |::||.|.|:||.|||:||:.||.|....:|||..:...:.:|..:|||.:|| |.|..|.||||
pombe  1010 EHYIQARGMRRAEDVRKQLIRLMDRYRHPVVSCGRKRELILRALCSGYFTNVAKRDSHEGCYKTI 1074

  Fly   817 KHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYK-AKELEDSTN 880
            ..|..|.:||:..||.:...||:||||:.||||||..|..:..|||:||||.::| |...:.|..
pombe  1075 VENAPVYMHPSGVLFGKAAEWVIYHELIQTSKEYMHTVSTVNPKWLVEVAPTFFKFANANQVSKT 1139

  Fly   881 KKMPKV 886
            ||..||
pombe  1140 KKNLKV 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	357/645 (55%)
		DEXDc	269..408	CDD:238005	92/138 (67%)
		HELICc	491..581	CDD:197757	56/89 (63%)
		HA2	651..735	CDD:214852	40/83 (48%)
		OB_NTP_bind	770..869	CDD:285018	47/99 (47%)
prp22	NP_593253.1	Pnp	1..>441	CDD:224106	22/151 (15%)
		S1_DHX8_helicase	207..287	CDD:240189
		DEXDc	506..692	CDD:214692	116/185 (63%)
		DEXDc	527..666	CDD:238005	92/138 (67%)
		HELICc	737..841	CDD:197757	64/103 (62%)
		HA2	909..992	CDD:214852	40/83 (48%)
		OB_NTP_bind	1026..1125	CDD:285018	45/98 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	6	5.720