Protein Alignment l(2)37Cb and gih35

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_593629.1
• Gene: gih35 / 2542874
• PomBaseID: SPAC20H4.09
• Length: 647
• Species: Schizosaccharomyces pombe
• Alignment Length: 640
• Identity: 249/640 - (38%)
• Similarity: 380/640 - (59%)
• Gaps: 20/640 - (3%)

  Fly   245 LDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRV 309
            |:..::.||:..::..|:.||:::|:.|:.|.||.|||||:||:|.|||:.....:||||||||:
pombe    18 LNIQKKLLPITKYRNQLLYAVEQNQITIVLGHTGCGKTTQIPQFLYEAGWASQNGIIGCTQPRRL 82

  Fly   310 AAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDE 374
            .|.||:.||:.|:....|:..||||:|:...|::|.:||||||.|..|...:|.|..||::|:||
pombe    83 VAKSVSERVSLELNSPPGSLCGYSIQFDHNVSEKTKIKYMTDGILLNEIFFDPLLERYSIVILDE 147

  Fly   375 AHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFF--DDAPIFRIPGRRYPVDIFYT 437
            .|||||.||:|.|::|.|...|.:.:|::|||::||.|.|.||  |......|.|:.:||:..:.
pombe   148 VHERTLSTDLLLGVLKRILEKRNDFRLVLSSASVDANKLSQFFGQDKVCTMSIEGKLFPVETLFL 212

  Fly   438 KAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYA 502
            :.|..:|:|:...:|:.|::|.|.|||||||:|:.|||.|.:.:.|.:.......:.|:.:|::|
pombe   213 QKPTENYVDSAIETVININSTYPPGDILVFLSGRKEIEYCIKKIEDSLIHASEDCQTLVPLPLHA 277

  Fly   503 NLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPI 567
            .|..|.|.::|.....:.||||.:|||||||:|||.|:||:|.||.||..:|..|....|:.|||
pombe   278 GLTVDEQMRVFNIYDGDFRKVIFSTNIAETSITIDGIVYVVDSGFNKQRIYNPYTRTSKLINVPI 342

  Fly   568 SKASANQRAGRAGRTAPGKCFRLYTAWAY---KHELEDNTVPEIQRINLGNAVLMLKALGINDLI 629
            ||:||.||:||||||..||.|||||..||   |.|.|    .:|...::...||.||.||:.:::
pombe   343 SKSSAIQRSGRAGRTMRGKVFRLYTEKAYSLMKEEFE----ADILNCDMSPLVLFLKGLGLKNIL 403

  Fly   630 HFDFLDPPPHETLVLALEQLYALGALNHHGELT-KLGRRMAEFPVDPMMGKMLLASEKYKCSEEM 693
            .|.|...||...|:.|||.||.||.|:..|.|| .||.:::...:|..:.|.||.|.::.|:.|:
pombe   404 QFPFFVRPPTVHLMAALEDLYLLGVLDESGNLTDPLGIQISNSFLDANISKALLTSNQFGCTHEI 468

  Fly   694 VTIAAMLSVNSAIFYRPKDKIIH-ADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQ 757
            ::||::|:... :||.|.....: |..|..:|....||.::.|.|:..:.......|||.:|::.
pombe   469 LSIASILTAGE-VFYNPTSSSKNDAFVAHSSFFANEGDIITALNVFESFVGNKKDLQWCRKNYLN 532

  Fly   758 YRSMKRARDVREQLVGLMQRVEIDMVSCLP--ETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQ 820
            |:::::|.|:|..||..:.:..|.....||  :...:.|....|:..:||.|...|.||||...|
pombe   533 YQTLRQALDIRTHLVRFLNKFSIPTAQRLPSSDCSKILKCLLDGFVRNVAHLQNDGSYKTIGGKQ 597

  Fly   821 TVMIHPNSSLFEELPRWVLYHELVFTSKE-YMRQVIEIESKWLLEVAPHYYKAKE 874
             |.:..:|.|.|:...|::|...|.:..: :::.:.:|||.||    ..|||.::
pombe   598 -VWLDSSSVLHEKKTPWIMYSSAVESETQIFVKNISKIESFWL----DKYYKREK 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	6/21 (29%)
		HrpA	251..>868	CDD:441249	245/626 (39%)
gih35	NP_593629.1	HrpA	25..>627	CDD:441249	240/607 (40%)