Protein Alignment l(2)37Cb and prh1

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_593091.1
• Gene: prh1 / 2541750
• PomBaseID: SPAC2G11.11C
• Length: 719
• Species: Schizosaccharomyces pombe
• Alignment Length: 751
• Identity: 319/751 - (42%)
• Similarity: 461/751 - (61%)
• Gaps: 54/751 - (7%)

  Fly   135 IAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDA 199
            :.|...|.|....|.:.|:...|..|:|.         |.||.::.:..::....
pombe     1 MVKVSGKLRNGGSITKQNLTDGLVGGQRI---------KAPNKKKNRKASKNTTK---------- 46

  Fly   200 KAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAA 264
            |:.......|:...|| .|..:.||...|..::.|.:..:||.:.  |.|::||::...:.|...
pombe    47 KSTVSVVNFLEQDTDF-GANEVVGSDNSSPEKRSENSPSKRKDIL--EQRKNLPIWEAHDTLCQQ 108

  Fly   265 VKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGC---TQPRRVAAMSVAARVAEEMGVKL 326
            :::::|:::.|||||||:||:||:|.|..:.::    ||   ||||||||:::|.|||.|.|.:|
pombe   109 IQDNRVIVVVGETGSGKSTQIPQFLNECPYAQE----GCVAITQPRRVAAVNLAKRVAAEQGCRL 169

  Fly   327 GNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKD 391
            |.:|||||||:|.||.:|.:||:|||.|.||.:::|.|:.|..:|:||||||||.||:|.|.||.
pombe   170 GEQVGYSIRFDDTTSKKTRIKYLTDGMLLRELINDPILSQYHTLILDEAHERTLMTDMLLGFVKK 234

  Fly   392 IARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIH 456
            |.:.||.|:::|.||||:||:||.|||.|.|..|.||:|||.|.||..||.||:|||..::.|:|
pombe   235 IIKKRPALRVIIMSATLNAERFSEFFDGAEICYISGRQYPVQIHYTYTPEPDYLDACLRTIFQLH 299

  Fly   457 ATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNAR 521
            ...|.||||||||||||||..:.::....|:|.|.:.::...|::|:||.:.|.::|.|...|.|
pombe   300 TKLPPGDILVFLTGQDEIEALEALIKSYSKQLPSNLPQIQACPLFASLPQEQQLQVFLPALANHR 364

  Fly   522 KVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGK 586
            ||:|:|||||||:||..|.||||.|.||...|||:.|:|||.|.|||:::|.||:|||||.|.|:
pombe   365 KVVLSTNIAETSVTISGIRYVIDTGLAKIKQFNSKLGLESLTVQPISQSAAMQRSGRAGREAAGQ 429

  Fly   587 CFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYA 651
            |:|:||. |...:|...|:|||:||:|..|||.|||.|.||:|:|.::|||..|.|:.|||.||:
pombe   430 CYRIYTE-ADFDKLPKETIPEIKRIDLSQAVLTLKARGQNDVINFHYMDPPSKEGLLRALEHLYS 493

  Fly   652 LGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIH 716
            :|||:.:|.:..||.:|:..|:.|.:.:.:||:.::.|..|::.:.:.||.:| :|..|::|...
pombe   494 IGALDDNGHINDLGYQMSLIPLLPSLARAVLAAREHNCLSEVIDVVSCLSTDS-MFLFPQEKRDE 557

  Fly   717 ADTARKNFNHMHGDHLSLLQVYNQWAETDYST--QWCYENFIQYRSMKRARDVREQLVGLMQRVE 779
            |..||..|.|..||.|:.|....|:.|:.:.:  |||.:|||..|::|...|:|:||
pombe   558 AIEARLKFLHSEGDLLTCLNALRQYLESSHDSRKQWCSQNFINRRALKTILDIRKQL-------- 614

  Fly   780 IDMVSCL---------PE--TVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLFEE 833
              ...||         ||  :.|:..:..:||..:.|.|...|.|:||..|||:.|||:||||.:
pombe   615 --REHCLKDGWELNSSPEVNSENLLLSFLSGYITNTALLHPDGSYRTIIGNQTISIHPSSSLFGK 677

  Fly   834 LPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHY 869
            ....::|||||||:|.|:|.|..|.|.||..|||||
pombe   678 KVEAIMYHELVFTTKSYVRGVSSIRSNWLNAVAPHY 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	27/131 (21%)
		HrpA	251..>868	CDD:441249	292/632 (46%)
prh1	NP_593091.1	HrpA	95..>719	CDD:441249	295/635 (46%)