DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and prp43

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_595937.1	Gene:	prp43 / 2540057	PomBaseID:	SPBC16H5.10c	Length:	735	Species:	Schizosaccharomyces pombe

Alignment Length:	655	Identity:	330/655 - (50%)
Similarity:	457/655 - (69%)	Gaps:	20/655 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 ETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTK-DKKMIGCTQPRRVA 310
            ||||.||||..:|:.:....|:|:::..||||||||||:||:::...... ....|.||||||||
pombe    70 ETRRELPVYQQREEFLKIYHENQIIVFVGETGSGKTTQIPQFVLYDELPHLTNTQIACTQPRRVA 134

  Fly   311 AMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEA 375
            |||||.|||:||.|.||.||||:||||||:...|:|||||||.|.||.:::..|:.||.:|:|||
pombe   135 AMSVAKRVADEMDVDLGEEVGYNIRFEDCSGPNTLLKYMTDGMLLREAMTDHMLSRYSCIILDEA 199

  Fly   376 HERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAP 440
            |||||.||||.||:|.:|..||:||:::.||||||:||..:|.|||:..:|||.|||:|:||:.|
pombe   200 HERTLATDILMGLMKRLATRRPDLKIIVMSATLDAKKFQKYFFDAPLLAVPGRTYPVEIYYTQEP 264

  Fly   441 EADYIDACCVSVLQIHATQPLGDILVFLTGQDEIE-TCQEVL--HDRVKRLGSKIRELIVIPVYA 502
            |.||::|...:|||||..:..|||||||||::||| .|:::.  .|.:.|.|: ...|.|.|:|.
pombe   265 ERDYLEAALRTVLQIHVEEGPGDILVFLTGEEEIEDACRKITLEADDLVREGA-AGPLKVYPLYG 328

  Fly   503 NLPSDMQAKIFEPTPPN-----ARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESL 562
            :||.:.|.:||||||.:     .|||:::|||||||||||.|:||:||||:||..:|.|..:|||
pombe   329 SLPPNQQQRIFEPTPEDTKSGYGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKIYNPRIRVESL 393

  Fly   563 MVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGIND 627
            :|.|||||||.|||||||||.|||||||||..|::.||.:.|.|||.|.||.:.||.||.|||:|
pombe   394 LVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFRKELIEQTYPEILRSNLSSTVLELKKLGIDD 458

  Fly   628 LIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEE 692
            |:|||::|||..||::.|||:|..|..|:.:|:||.|||:.:|||:||.:..||:.|.::.||.|
pombe   459 LVHFDYMDPPAPETMMRALEELNYLNCLDDNGDLTPLGRKASEFPLDPNLAVMLIRSPEFYCSNE 523

  Fly   693 MVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQ 757
            ::::.|:|||.: :|.||......||..|:.|.|..||||:||.||:.:...:.:..||:.:|:.
pombe   524 VLSLTALLSVPN-VFVRPNSARKLADEMRQQFTHPDGDHLTLLNVYHAYKSGEGTADWCWNHFLS 587

  Fly   758 YRSMKRARDVREQLVGLMQRVEIDMVSCLPET----VNVRKAATAGYFYHVARLSKGG-HYKTIK 817
            :|::..|.:||:||...|:|.|::::|...:.    ||:|:|..:|:|..||:.|..| :|.|:|
pombe   588 HRALISADNVRKQLRRTMERQEVELISTPFDDKNYYVNIRRALVSGFFMQVAKKSANGKNYVTMK 652

  Fly   818 HNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELEDSTNKK 882
            .||.|.:||:..| ...|.||:|:|.|.|:|.::|.|..|..:||:|:||:||   :|:|..|.|
pombe   653 DNQVVSLHPSCGL-SVTPEWVVYNEFVLTTKSFIRNVTAIRPEWLIELAPNYY---DLDDFDNNK 713

  Fly   883 MPKVA 887
            ..|.|
pombe   714 EVKSA 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	320/633 (51%)
		DEXDc	269..408	CDD:238005	82/139 (59%)
		HELICc	491..581	CDD:197757	55/94 (59%)
		HA2	651..735	CDD:214852	35/83 (42%)
		OB_NTP_bind	770..869	CDD:285018	41/103 (40%)
prp43	NP_595937.1	DEXDc	80..258	CDD:214692	100/177 (56%)
		DEXDc	92..232	CDD:238005	82/139 (59%)
		HELICc	257..421	CDD:238034	92/164 (56%)
		HA2	482..565	CDD:214852	35/83 (42%)
		OB_NTP_bind	599..703	CDD:285018	41/104 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	6	5.720