DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and prp16

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_595890.2	Gene:	prp16 / 2540006	PomBaseID:	SPBC1711.17	Length:	1173	Species:	Schizosaccharomyces pombe

Alignment Length:	964	Identity:	384/964 - (39%)
Similarity:	561/964 - (58%)	Gaps:	138/964 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRTASSSSSGEEPDSEEES--RLKDLQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLK 69
            :|.:.||.||...:|...|  |....|..:..:|:.:.|..:.:|..|||:             |
pombe   191 RRNSYSSWSGSNFESSNGSNRRRYRTQMEEPLSSKRRNRFGNGSRRDVDSS-------------K 242

  Fly    70 LEHED------------RDKIVPHLRLQSRRQYLEKRKDDKVAELEAD---------ILDDE--- 110
            ..|:.            ||...|....:|:..  .:|.:::.|.|:.|         :|.||
pombe   243 YSHDSDYSYGAHSSWDARDVEYPEEDPESKAD--RQRWEEEQAHLDRDWYMNSESQNLLGDEVHN 305

  Fly   111 -YLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQRYNM-------PQDLKKG------- 160
             :...|:|      |:|.::.:.:...|:|......:|.:..:|       ...:.|.
pombe   306 PFSDFETV------EDRAHEAEFIEKQKKHLSIEASDRFKENSMWEKNRMITSGVSKAPGLESDY 364

  Fly   161 ----ERSEYVEVDEFE--------------------KQPNS--------------EQKKW-EAEQ 186
                ||..::.|||..                    :.|.|              |:::: |.::
pombe   365 SLMEERRVHLLVDELRPHFLDGAEFSSKKVGDITSVRDPQSDLAINARLGSRLVRERREFRERQK 429

  Fly   187 LASARFH---------FGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKR 242
            .|||...         .|.||:..|        |.......:.:.|..|:|:.:..|....:..|
pombe   430 AASAATSLAGTSLGNVMGLKDSNDE--------DAKAGTTPVKVAGRSEQSNKKDTEFARTKSYR 486

  Fly   243 LTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPR 307
                |.|..||.:..:|.|::.::::||||:.||||||||||:.|:|.|.|:.:: .||||||||
pombe   487 ----EQREFLPAFAVREQLLSVIRDNQVLIVVGETGSGKTTQLAQFLYEDGYHRN-GMIGCTQPR 546

  Fly   308 RVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMII 372
            ||||||||.||:|||||:||:.|||||||||.|...|::||||||.|.||.|.:.:|..|||:|:
pombe   547 RVAAMSVAKRVSEEMGVRLGSTVGYSIRFEDVTGPDTVIKYMTDGVLLRESLMQNNLEKYSVIIM 611

  Fly   373 DEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYT 437
            ||||||:|:||||.||:|.:...|.::|||::|||::::|||.||..||.|.||||.|||||.:.
pombe   612 DEAHERSLNTDILMGLLKKVLSRRRDIKLLVTSATMNSQKFSDFFGGAPQFTIPGRTYPVDIMFA 676

  Fly   438 KAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYA 502
            |||.:||::|....|||||.:||.||||||:|||::||...|::.||:.:|....| |.::|:|:
pombe   677 KAPCSDYVEAAVRQVLQIHLSQPAGDILVFMTGQEDIEATCEIIADRLNQLHDAPR-LSILPIYS 740

  Fly   503 NLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPI 567
            .:|:|:|||||:...|..|||::||||||||||:..|.||:|.|:.|...:||:.|:::|.|.||
pombe   741 QMPADLQAKIFDSAEPGVRKVVVATNIAETSLTVHGISYVVDTGYCKLKMYNSKLGIDTLQVTPI 805

  Fly   568 SKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFD 632
            |:|:|||||||||||.||..:||||..||..|:.:.|:|||||.||.|.||:||:||:.::..||
pombe   806 SQANANQRAGRAGRTGPGIAYRLYTEMAYIREMFETTLPEIQRTNLSNTVLILKSLGVEEISDFD 870

  Fly   633 FLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIA 697
            |:|.||::||:.:|.:|:.||||::.|:||.||::|:.||:||.:.|:::.:|.|||:||::||.
pombe   871 FMDRPPNDTLMASLYELWTLGALDNFGKLTTLGKKMSLFPMDPSLSKLIIIAEDYKCTEEIITIV 935

  Fly   698 AMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMK 762
            :||||.| :|||||::...:|.||:.||....|||.||.:|..|....||..||.::|:..:::|
pombe   936 SMLSVPS-VFYRPKERAEESDAAREKFNVPESDHLMLLNIYQHWQRNGYSNSWCSKHFLHSKTLK 999

  Fly   763 RARDVREQLVGLMQRVEIDMVSCLPETVN----VRKAATAGYFYHVARLSKG-GHYKTIKHNQTV 822
            ||||:|:|||.:|.:.:|.:     |:|:    ||:...:.|| |.|..:|| |.|..::.....
pombe  1000 RARDIRQQLVEIMSKQKISL-----ESVSDWDIVRRVLCSAYF-HQAACAKGIGEYVHLRSGMPC 1058

  Fly   823 MIHPNSSLF--EELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKE 874
            .:|..|||:  ..||.:|:|||||.||||||..|..::..||.|....||..||
pombe  1059 HLHVTSSLYGLGYLPDYVIYHELVLTSKEYMNIVTSVDPYWLAEFGGVYYSVKE 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	326/651 (50%)
		DEXDc	269..408	CDD:238005	89/138 (64%)
		HELICc	491..581	CDD:197757	48/89 (54%)
		HA2	651..735	CDD:214852	41/83 (49%)
		OB_NTP_bind	770..869	CDD:285018	39/105 (37%)
prp16	NP_595890.2	DEXDc	487..673	CDD:214692	111/186 (60%)
		DEXDc	509..647	CDD:238005	89/138 (64%)
		HELICc	718..821	CDD:197757	54/103 (52%)
		HA2	890..972	CDD:214852	41/82 (50%)
		OB_NTP_bind	998..1107	CDD:285018	45/114 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	5	4.710