DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)37Cb and Ythdc2

DIOPT Version :9

Sequence 1:NP_609946.1 Gene:l(2)37Cb / 35192 FlyBaseID:FBgn0086444 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:1136 Identity:277/1136 - (24%)
Similarity:450/1136 - (39%) Gaps:370/1136 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 GGRRAIEEATKRLKLEHEDRDKIVPHLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTK 120
            ||.||  :..|.::::.|  .||..::.|: |.:|.::|      |:|         |..| ||.
Mouse    44 GGGRA--KGLKDIRIDEE--VKIAVNIALE-RFRYGDQR------EME---------FPSS-LTS 87

  Fly   121 REKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGE-RSEYVEVDEFEKQPNSEQKKWEA 184
            .|:            |..|..::.|..:.:       .||: .:.|:.|   :|:..||    .|
Mouse    88 TER------------AFIHRLSQSLGLVSK-------SKGKGANRYLTV---KKKDGSE----TA 126

  Fly   185 EQLASARFHFGAKDA----------KAEEEYELLLDDQIDFIQALTLDGSRE--KSSSRQ----P 233
            ..:.:.......|.|          ..:|..|||...:...:.|:..: :||  |:|.|.    |
Mouse   127 HAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAE-NREMSKTSGRLNNGIP 190

  Fly   234 ELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKD- 297
            ::..| |.....|..|:||||:..:|:::..:||::|::|.||||||||||:||:|::..|... 
Mouse   191 QVPVK-RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGI 254

  Fly   298 KKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLS-E 361
            ...|.||||||:||::||.|||.|...::|..:||.||.|...|.:|:|.:.|:|.|.|..:: :
Mouse   255 PCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGD 319

  Fly   362 PDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIP 426
            ..|::.:.:|:||.|||...:|.|...::|:.:..|.|||::|||.||...|..:|...|:..|.
Mouse   320 STLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQ 384

  Fly   427 GRRYPV----------------------------------------------------------- 432
            ||.:.|                                                           
Mouse   385 GRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVAS 449

  Fly   433 ------------DIFYTKAPEADY----------IDAC--------------------------- 448
                        |..:::..|.|.          :|||                           
Mouse   450 VSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSV 514

  Fly   449 -------------------------------------------------------CVSVLQIHAT 458
                                                                   .|.:|:.::.
Mouse   515 DYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSA 579

  Fly   459 Q-------------------------------------------------------PLGDILVFL 468
            .                                                       ..|.||:||
Mouse   580 SLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFL 644

  Fly   469 TGQDEIETCQEVLHDRV----KRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNI 529
            .|.|||..    |.||:    ||.........|..:::|:.:..|.|:.:..|...||:||:|||
Mouse   645 PGYDEIVG----LRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNI 705

  Fly   530 AETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAW 594
            ||||:|::::::|||.|..|:.:|::...:..|.:|.||||||.||.|||||..||.||||::..
Mouse   706 AETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRL 770

  Fly   595 AYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFL----DPPPHETLVLALEQLYALGAL 655
            .:::.||..| ||:.|:.|....|..|.|...:....|||    :|||...:..|::.|..:.|:
Mouse   771 RFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAM 834

  Fly   656 NHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKII----- 715
            :...:||:||..:|:.||:|.:|||:|.:...||.:.::|||..|:      ||  |..:     
Mouse   835 DAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLA------YR--DPFVLPTQA 891

  Fly   716 ----HADTARKNFN-HMHGDHLSLLQVYNQW--AETD-YSTQWCYENFIQYRSMKRARDVREQLV 772
                .|...||.|. ....||::||:.:..|  |.:| :...:|.:||:...:|:....:|.||:
Mouse   892 SQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLL 956

  Fly   773 GLMQRV---------EIDMVSCLPETVNVRKAA-TAGYFYHVARLSKGGHYKTIKHNQTVMIHPN 827
            |.::..         :|..|:...|...|.||| .||.:.::..:.:.....|....:.|..||.
Mouse   957 GQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVILTGPKEKKVRFHPT 1021

  Fly   828 SSL----FEELP--------------RWVLYHE---------------------LVFTSKEYM-R 852
            |.|    ::::|              .|::|.|                     |||.....: .
Mouse  1022 SVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPARLAS 1086

  Fly   853 QVIEIESKWLLEVAPHYYKAKELEDSTNKKM 883
            ..::..|.:..:..|:.....|:||.|...:
Mouse  1087 NALQEPSSFRADGIPNDSSDSEMEDRTTANL 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)37CbNP_609946.1 HrpA 222..867 CDD:224557 235/941 (25%)
DEXDc 269..408 CDD:238005 61/140 (44%)
HELICc 491..581 CDD:197757 36/89 (40%)
HA2 651..735 CDD:214852 28/93 (30%)
OB_NTP_bind 770..869 CDD:285018 27/148 (18%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 4/7 (57%)
R3H_DEXH_helicase 61..119 CDD:100077 20/96 (21%)
DEXDc 225..364 CDD:238005 59/138 (43%)
DEAH box 331..334 2/2 (100%)
ANK 502..587 CDD:238125 2/84 (2%)
ANK repeat 520..552 CDD:293786 0/31 (0%)
ANK 1 521..553 0/31 (0%)
Ank_4 524..574 CDD:290365 1/49 (2%)
ANK 2 554..586 2/31 (6%)
ANK repeat 554..582 CDD:293786 2/27 (7%)
Helicase_C 625..757 CDD:278689 50/135 (37%)
HA2 831..916 CDD:214852 28/92 (30%)
OB_NTP_bind 954..1081 CDD:285018 25/126 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303
YTH 1304..1434 CDD:282058
N6-methyladenosine binding. /evidence=ECO:0000250|UniProtKB:Q9Y5A9 1309..1311
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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