DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)37Cb and Ythdc2

DIOPT Version :10

Sequence 1:NP_609946.1 Gene:l(2)37Cb / 35192 FlyBaseID:FBgn0086444 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:1136 Identity:277/1136 - (24%)
Similarity:450/1136 - (39%) Gaps:370/1136 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 GGRRAIEEATKRLKLEHEDRDKIVPHLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTK 120
            ||.||  :..|.::::.|  .||..::.|: |.:|.::|      |:|         |..| ||.
Mouse    44 GGGRA--KGLKDIRIDEE--VKIAVNIALE-RFRYGDQR------EME---------FPSS-LTS 87

  Fly   121 REKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGE-RSEYVEVDEFEKQPNSEQKKWEA 184
            .|:            |..|..::.|..:.:       .||: .:.|:.|   :|:..||    .|
Mouse    88 TER------------AFIHRLSQSLGLVSK-------SKGKGANRYLTV---KKKDGSE----TA 126

  Fly   185 EQLASARFHFGAKDA----------KAEEEYELLLDDQIDFIQALTLDGSRE--KSSSRQ----P 233
            ..:.:.......|.|          ..:|..|||...:...:.|:..: :||  |:|.|.    |
Mouse   127 HAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAE-NREMSKTSGRLNNGIP 190

  Fly   234 ELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKD- 297
            ::..| |.....|..|:||||:..:|:::..:||::|::|.||||||||||:||:|::..|... 
Mouse   191 QVPVK-RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGI 254

  Fly   298 KKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLS-E 361
            ...|.||||||:||::||.|||.|...::|..:||.||.|...|.:|:|.:.|:|.|.|..:: :
Mouse   255 PCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGD 319

  Fly   362 PDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIP 426
            ..|::.:.:|:||.|||...:|.|...::|:.:..|.|||::|||.||...|..:|...|:..|.
Mouse   320 STLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQ 384

  Fly   427 GRRYPV----------------------------------------------------------- 432
            ||.:.|                                                           
Mouse   385 GRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVAS 449

  Fly   433 ------------DIFYTKAPEADY----------IDAC--------------------------- 448
                        |..:::..|.|.          :|||                           
Mouse   450 VSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSV 514

  Fly   449 -------------------------------------------------------CVSVLQIHAT 458
                                                                   .|.:|:.::.
Mouse   515 DYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSA 579

  Fly   459 Q-------------------------------------------------------PLGDILVFL 468
            .                                                       ..|.||:||
Mouse   580 SLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFL 644

  Fly   469 TGQDEIETCQEVLHDRV----KRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNI 529
            .|.|||..    |.||:    ||.........|..:::|:.:..|.|:.:..|...||:||:|||
Mouse   645 PGYDEIVG----LRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNI 705

  Fly   530 AETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAW 594
            ||||:|::::::|||.|..|:.:|::...:..|.:|.||||||.||.|||||..||.||||::..
Mouse   706 AETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRL 770

  Fly   595 AYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFL----DPPPHETLVLALEQLYALGAL 655
            .:::.||..| ||:.|:.|....|..|.|...:....|||    :|||...:..|::.|..:.|:
Mouse   771 RFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAM 834

  Fly   656 NHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKII----- 715
            :...:||:||..:|:.||:|.:|||:|.:...||.:.::|||..|:      ||  |..:     
Mouse   835 DAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLA------YR--DPFVLPTQA 891

  Fly   716 ----HADTARKNFN-HMHGDHLSLLQVYNQW--AETD-YSTQWCYENFIQYRSMKRARDVREQLV 772
                .|...||.|. ....||::||:.:..|  |.:| :...:|.:||:...:|:....:|.||:
Mouse   892 SQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLL 956

  Fly   773 GLMQRV---------EIDMVSCLPETVNVRKAA-TAGYFYHVARLSKGGHYKTIKHNQTVMIHPN 827
            |.::..         :|..|:...|...|.||| .||.:.::..:.:.....|....:.|..||.
Mouse   957 GQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVILTGPKEKKVRFHPT 1021

  Fly   828 SSL----FEELP--------------RWVLYHE---------------------LVFTSKEYM-R 852
            |.|    ::::|              .|::|.|                     |||.....: .
Mouse  1022 SVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVFCGPARLAS 1086

  Fly   853 QVIEIESKWLLEVAPHYYKAKELEDSTNKKM 883
            ..::..|.:..:..|:.....|:||.|...:
Mouse  1087 NALQEPSSFRADGIPNDSSDSEMEDRTTANL 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)37CbNP_609946.1 PTZ00121 <6..267 CDD:173412 52/227 (23%)
HrpA 251..>868 CDD:441249 225/907 (25%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 4/7 (57%)
R3H_DEXH_helicase 61..119 CDD:100077 20/96 (21%)
PRK11131 203..>1033 CDD:182986 218/842 (26%)
DEXHc_YTHDC2 208..383 CDD:350745 72/174 (41%)
DEAH box 331..334 2/2 (100%)
ANK repeat 520..552 CDD:293786 0/31 (0%)
ANK 1 521..553 0/31 (0%)
ANK 2 554..586 2/31 (6%)
ANK repeat 554..582 CDD:293786 2/27 (7%)
SF2_C_RHA 612..767 CDD:350178 57/158 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303
YTH 1304..1433 CDD:410979
Blue background indicates that the domain is not in the aligned region.

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