Protein Alignment l(2)37Cb and DHX30

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 962
• Identity: 269/962 - (27%)
• Similarity: 425/962 - (44%)
• Gaps: 180/962 - (18%)

  Fly    12 SSSSGEEPDSEEESRLKD-LQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDR 75
            |.|.|.|.:.:||..|:: ..:..:|.|..::   |....:.||.|.           ..|..|.
Human   253 SRSLGREEEEDEEEELEEGTIDVTDFLSMTQQ---DSHAPLRDSRGS-----------SFEMTDD 303

  Fly    76 DKIVPHLRLQSRRQY-LEKRKDDKVAELEADILDDEYLFD-ESVLTK------------------ 120
            |..:     ::..|: |.|....||.::.......:.|.. .:|.||
Human   304 DSAI-----RALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLSTLTLLWPCPMTFVA 363

  Fly   121 --REKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQ---- 179
              |.|.|.|.|...|..    :|.:.|..:.|.|.|........:...|:.|.:::|.:.|
Human   364 KGRRKAEAENKAAALAC----KKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEP 424

  Fly   180 --KKWEAEQLASARF--HFGAKDAKAEEEYELLLDDQIDFIQALTLD-GSREKSSSRQP--ELTE 237
              :|.|.       |  |:..:.:....|..|..||    |..|..| |......:.:|  .|.|
Human   425 ILRKIET-------FLNHYPVESSWIAPELRLQSDD----ILPLGKDSGPLSDPITGKPYVPLLE 478

  Fly   238 KERKRLT---LDETRR---------SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLV 290
            .|..||:   |:..||         .|||.|.::.::.|:::|.|::|.|:||.||||::||.|:
Human   479 AEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLL 543

  Fly   291 EAGFTKDKKM---IGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDR-TILKYMTD 351
            |...|:.:..   :..|||||::|:|||.||:.|:|..|...||:.:|.|.....| ..|.:.|.
Human   544 ERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTV 608

  Fly   352 GTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAF 416
            |.|.|:..|.|.|...|.:|:||.|||.::||.|..|:|.:.|..|.|:|::.|||.|.|:||.:
Human   609 GILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRY 673

  Fly   417 FDDAPIFRIPGRRYPVDIFY-----TKAPEADYI---------DACCVS-------VLQIHATQP 460
            |...|:.::||..|||...|     .|..:..|:         |.|.:.       ||.|.|...
Human   674 FGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHIDARGE 738

  Fly   461 LGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVIL 525
            .|.||.||.|..||:..|:.|.:   .||....:.:::||::|:|...|..||:..|...||::|
Human   739 PGGILCFLPGWQEIKGVQQRLQE---ALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVL 800

  Fly   526 ATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRL 590
            ||||||||:||::|::|:|.|..|:..::.:|.:..|..|.:|:|:..||.|||||...|..:.|
Human   801 ATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHL 865

  Fly   591 YTAWAYKHELEDNT---VPEIQRINLGNAVLMLKALGINDLIHF------DFL----DPPPHETL 642
            :.    :..||...   ||||.|..|.|.||..|       ||.      :||    |.|..:.:
Human   866 FP----RSRLEKMVPFQVPEILRTPLENLVLQAK-------IHMPEKTAVEFLSKAVDSPNIKAV 919

  Fly   643 VLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLS---VNS 704
            ..|:..|..:|.|:....||.||:|:|....||.:.|.::.:..::|...::.:.:.|:   .:|
Human   920 DEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSS 984

  Fly   705 AIFYRPKDKIIHADTARKNFNHMHG-DHLSLLQVYNQWAET----DYSTQWCY--ENFIQYRSMK 762
            ::..|.:     .|..:...:|..| |||:.::....|.|.    |.|::..|  ||.:...|::
Human   985 SLQNRAE-----VDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLR 1044

  Fly   763 RARDVREQ---------LVGLMQRVEIDMVSC---LPETVNVRKAATAGYFYHVARLSKG----- 810
            ....:.:|         |||......:....|   ..|...|:....||.:.::.::.:|
Human  1045 FIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQ 1109

  Fly   811 GHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWL 862
            |.:|           |||..:......:|.|:....     |:...:.|:||
Human  1110 GKFK-----------PNSVTYRTKSGNILLHKSTIN-----REATRLRSRWL 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	66/300 (22%)
		HrpA	251..>868	CDD:441249	208/677 (31%)
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	183/550 (33%)
		OB_NTP_bind	1086..1173	CDD:400182	15/76 (20%)