DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and Dhx8

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_659080.2	Gene:	Dhx8 / 217207	MGIID:	1306823	Length:	1244	Species:	Mus musculus

Alignment Length:	1066	Identity:	444/1066 - (41%)
Similarity:	613/1066 - (57%)	Gaps:	192/1066 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNRKRTASSSSSGEEPDSEEESRLKDLQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRL 68
            |.:||:.|.....:.....:..|.:| ::||:...|.:.|:.||.|   |.....:....:..|.
Mouse   172 KKKKRSRSRDRDRDRDRDRDRDRDRD-RDRDKDRERDRDRERDRER---DRERDHKRRHRSRSRS 232

  Fly    69 KLEHEDRDKIVPHLRLQSRRQY-LEKRKD-DKVAELEADILDDEY-------------LFDESV- 117
            .....:|.|.....|.:||.|. .:.||| :|..|...|...|::             :::..|
Mouse   233 HSRTRERTKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPAIGDIYNGKVT 297

  Fly   118 -------------LTKREK-----EEREYKKQLLNIAK--------------------------- 137
                         |.||.:     .|...:.::.|:|.
Mouse   298 SIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDV 362

  Fly   138 EHEKARELERIQRYNMPQDLKKGERSE-------------------YVEVDEFEKQ---PNSEQK 180
            :.|...:|...:|.|:     .||.:|                   .||.|..|::   ..|:.:
Mouse   363 DQETGEDLNPNRRRNL-----VGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPE 422

  Fly   181 KWEAEQLASARF-------HFGAK-------DAKAEEEYEL-LLDDQIDFIQALTL--------- 221
            |||.:|:.:|..       .|..:       |.:.:|:.|: |::::..|::..|.
Mouse   423 KWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIK 487

  Fly   222 -----DGSREKSSSRQPELTEKERK---------------------------------------- 241
                 |||..:::..|..|.::.|:
Mouse   488 IVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGI 552

  Fly   242 --------------------------RLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSG 280
                                      ::::.|.|.|||:|..||.|:.||.::|:||:.||||||
Mouse   553 GMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSG 617

  Fly   281 KTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTI 345
            ||||:.|||.|||:|...| |||||||||||||||.||:||.|..||.||||:||||||||..|:
Mouse   618 KTTQITQYLAEAGYTSRGK-IGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETV 681

  Fly   346 LKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDA 410
            :||||||.|.||.|.:|||..|:::::|||||||:|||:||||:|...:.|.::||:::||||||
Mouse   682 IKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDA 746

  Fly   411 EKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIE 475
            .|||.:|.:||||.||||.|||:|.|||.||.||:||..::|:|||.|:|.||||||||||:||:
Mouse   747 VKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEID 811

  Fly   476 TCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNII 540
            |..|:|::|:|.||..:.|||::|||:.|||:||.:||:|.||.:|||::||||||||||||.|.
Mouse   812 TACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIY 876

  Fly   541 YVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTV 605
            ||:||||.||..:||:||::.|:|.|||:|.|.|||||||||.||||:||||..||:.|:....|
Mouse   877 YVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNV 941

  Fly   606 PEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAE 670
            |||||.||.:.||.|||:|||||:.|||:|.||.|||:.|:||||.||||:..|.||:|||||||
Mouse   942 PEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAE 1006

  Fly   671 FPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLL 735
            ||::||:.|||:.|....|||||:||.:||||.: :|||||||...||..:..|:...||||:||
Mouse  1007 FPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTEGDHLTLL 1070

  Fly   736 QVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGY 800
            .|||.|....:|..||||||||.||::||:|:|:|::|:|.|.::|:|||...||.|:||..:|:
Mouse  1071 AVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGF 1135

  Fly   801 FYHVARLSKGGHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEV 865
            |.:.|:......|:|:...|.|.|||:|:||...|.||:|||||.|:|||||:|..|:.:||:|.
Mouse  1136 FRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1200

  Fly   866 APHYYKAKELEDSTNKKMPKVAGRAE 891
            ||.::|   :.|.|.....|...|.|
Mouse  1201 APAFFK---VSDPTKLSKQKKQQRLE 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	377/710 (53%)
		DEXDc	269..408	CDD:238005	90/138 (65%)
		HELICc	491..581	CDD:197757	57/89 (64%)
		HA2	651..735	CDD:214852	47/83 (57%)
		OB_NTP_bind	770..869	CDD:285018	47/98 (48%)
Dhx8	NP_659080.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..289		28/120 (23%)
		S1_DHX8_helicase	289..367	CDD:240189	8/77 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..396		7/39 (18%)
		DEXDc	585..770	CDD:214692	119/185 (64%)
		DEXDc	606..744	CDD:238005	90/138 (65%)
		DEAH box	709..712		2/2 (100%)
		HELICc	769..926	CDD:238034	99/156 (63%)
		HA2	988..1070	CDD:214852	47/82 (57%)
		OB_NTP_bind	1104..1203	CDD:285018	46/98 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730