DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and Dhx37

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_017176254.1	Gene:	Dhx37 / 208144	MGIID:	3028576	Length:	1161	Species:	Mus musculus

Alignment Length:	1030	Identity:	303/1030 - (29%)
Similarity:	450/1030 - (43%)	Gaps:	277/1030 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 RRQYLEK---RKDDKVA----------ELEA-DILDDEYLFDES-VLT---KREKEER---EYKK 130
            ||:|..|   :.|.:.|          |||. |:|..   .||| ||.   ||:|:.:   ..||
Mouse     5 RRRYNVKGRLQADPRPAKGPEAPPVRLELEGKDVLKG---VDESNVLVLPGKRKKKTKAPPPSKK 66

  Fly   131 QLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQ--------- 186
            :...:.|:..|.  |:::    :.|..||.:|:|.:       |..||.:..|||.
Mouse    67 ERKPLTKKERKV--LQKV----LEQKEKKSQRAELL-------QKLSEVQVSEAEMSLFYTTAKL 118

  Fly   187 -LASARFHF-----GAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLT- 244
             .....:|.     |...|:.:|:...|........::.:.:...|.|...:||....::.|.:
Mouse   119 GTGDRMYHIKERKSGQPAARGQEKVSSLSGAHRKRHRSSSTEEDSESSEDSEPEEATADQPRTST 183

  Fly   245 ---------------------------------------------------------LDETRRSL 252
                                                                     :.|.|..|
Mouse   184 GTEPVHPPPAPSGINSPAPTPQPPPSGISAPPKTPASAPPPPVAKPAVFIPVNRTPEMQEERLKL 248

  Fly   253 PVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAAR 317
            |:...::.::.||.||.::|:.|||||||||||||:|.|||::.:..:||.|:||||||::::.|
Mouse   249 PILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSIIGVTEPRRVAAVAMSQR 313

  Fly   318 VAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHT 382
            ||:||.:. ...|.|.||:|...::.|.:|:||||.|.:|...:..|..|.|:||||||||:::|
Mouse   314 VAKEMNLS-HRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYT 377

  Fly   383 DILFGLVKDIARFRPE----LKLLISSATLDAEKFS----AFFDDAPIFRIPGRRYPVDIFYTK- 438
            |||.||:..|...|.:    |||||.||||..|.|:    .|....|:.::..|::||.:.:.|
Mouse   378 DILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTPPPVIKVESRQFPVTVHFNKR 442

  Fly   439 APEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIET-CQEV---------------------- 480
            .|..||...|...|.:||...|.|.||||||||.|:.. |:.:
Mouse   443 TPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPFRCSQPQEKEEDSAEGM 507

  Fly   481 -----------------------------------------LHDRVKRLGSKI------------ 492
                                                     :.|..:.|||.:
Mouse   508 RRFKKSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEALGSDLDLDLGDSEANEG 572

  Fly   493 ------RELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQN 551
                  ..|.|:|:|:.|..:.||::|:|.|...|..::|||:|||||||..|.||:|.|..|:.
Mouse   573 EQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKR 637

  Fly   552 NFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNA 616
            .::..||:.|..|..:|:|||:|||||||||.||.|:|||:: |...:.|....|||.|..:.:.
Mouse   638 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSS-AVFGDFEQFPPPEITRRPVEDL 701

  Fly   617 VLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGE---------------LTKLGR 666
            :|.:|||.|..:|:|.|..||..|.||.|.|.|.|||||....:               :|.|||
Mouse   702 ILQMKALSIEKVINFPFPTPPSVEALVAAEELLVALGALQAPPKQERMKKLQMSQLSCPITALGR 766

  Fly   667 RMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDH 731
            .|:.|||.|...|||..|:::.|....:.|.|.::|....     :::.....:.|....:.|..
Mouse   767 TMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELF-----EELDRPAASEKELAELKGRR 826

  Fly   732 LSLLQVYNQWA-------------------ETDY---STQWCYENFIQYRSMKRARDVREQLVGL 774
            ..:.|:...||                   ..:|   |.|:|..|.::|::|...|.:|.||...
Mouse   827 ARVAQMKRTWAGQGPSLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTA 891

  Fly   775 MQRVEIDMVSCLPE----------------TVNVRKAATAGYFYHVARLSKG---------GHYK 814
            :..|      | ||                ...:|:...||...|:||..:.         ..||
Mouse   892 VNAV------C-PEAGLFLDPKMQPPTESQVTYLRQIMAAGLGDHLARRVQSEDLLDPKWKNAYK 949

  Fly   815 TIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHY 869
            |...:..|.|||:|.||:|||.:|:|.|:|.|:|.||:.|..:|.:|:..:.|.|
Mouse   950 TPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSTVEIQWIPSLLPSY 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	261/855 (31%)
		DEXDc	269..408	CDD:238005	71/142 (50%)
		HELICc	491..581	CDD:197757	41/107 (38%)
		HA2	651..735	CDD:214852	24/98 (24%)
		OB_NTP_bind	770..869	CDD:285018	37/123 (30%)
Dhx37	XP_017176254.1	HrpA	236..1009	CDD:224557	258/783 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820