Protein Alignment l(2)37Cb and smgl-2

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001294374.1
• Gene: smgl-2 / 177135
• WormBaseID: WBGene00021365
• Length: 1089
• Species: Caenorhabditis elegans
• Alignment Length: 929
• Identity: 253/929 - (27%)
• Similarity: 410/929 - (44%)
• Gaps: 206/929 - (22%)

  Fly    96 DDKVAELEADILDDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQRY-NMPQDLKK 159
            |.:..|.....|...:|.||...:...:.|:..:::|::..:        :.||.| |.....:|
 Worm     5 DQEEYEKHRGALFRHFLPDEPGTSGNRRGEKSTEQELIDTQR--------KSIQSYFNRFFRERK 61

  Fly   160 GERSEYVEVDEF--------EKQPNSEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFI 216
            ||.:::.:|:..        :......:.:::.|.|.......|.........:|......:.|.
 Worm    62 GETNDHFDVNRVKFDDLGIPQDTGGLNRIRFKGENLGIMPTQLGHITPWLYRHFEYAYHVALQFN 126

  Fly   217 QALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGK 281
            |                  .:|.:|...|.:.::.||:.....:::..:|.:||||:.|:||.||
 Worm   127 Q------------------HQKFQKLQKLRKLQKELPIAERAGEIVELLKTNQVLIVAGDTGCGK 173

  Fly   282 TTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTIL 346
            :|||||||::||||.    :.||||||:|..::|.|||.|...:.|:||.:.||||...|.:|.|
 Worm   174 STQVPQYLLKAGFTG----VACTQPRRIACTALARRVAYETLNQYGSEVAFQIRFETTKSQKTKL 234

  Fly   347 KYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAE 411
            .::|:|.|.|:...:..|..|:|:|:||.|||.|.:|:|.||::|:...|.:|||::.|||::.:
 Worm   235 LFLTEGLLLRQMEKDSLLEKYNVIILDEVHERHLTSDLLIGLLRDLCTKRDDLKLILMSATINLD 299

  Fly   412 KFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQP---------------- 460
            .|..:|:.||:.::|||.:|:|:.:  .|...:||.   |..:.|...|
 Worm   300 LFKGYFEGAPVVQVPGRLFPIDVRW--HPIKQFIDQ---SDKKTHKIDPEPYLKILELIDKQFPS 359

  Fly   461 --LGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKV 523
              .||.|:||.|..||    .::.:.:|.........|::.:::.|..:.|.|:|:..|...||.
 Worm   360 TQRGDALIFLNGVAEI----SMVAEHLKNYAELTNGWIILMLHSTLSVEEQDKVFDQAPVGIRKC 420

  Fly   524 ILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCF 588
            ||:||:||||:|||.|.:|||.|..........||.:.|....:||||||||.||||||.||.|:
 Worm   421 ILSTNVAETSVTIDGIRFVIDSGKVNLIKHEPGTGTQKLTEFWVSKASANQRKGRAGRTGPGICY 485

  Fly   589 RLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGIN-DLIHFDFLDPPPHETLVLALEQLYAL 652
            |||:...:: :::|.||.||.|::|....|.:.:|.:. |...|.|::.|..:.|...||.|...
 Worm   486 RLYSQEQFE-KMDDFTVSEINRVSLQEMALKMISLNLGLDPRTFPFIEKPSEDVLNEGLEVLKFQ 549

  Fly   653 GAL-NHHGE---LTKLGRRMAEFPVDPMMGKMLLASEKYKC----SEEMVTIAAMLSVNSAI--- 706
            ..| :..|:   ||.||..:::.||:..:.|||:    |.|    .|.|:|:||.|||.|..
 Worm   550 RVLRSDRGDILTLTALGNMVSKLPVEVPIAKMLV----YGCVVDELEVMLTVAAGLSVQSPFTNR 610

  Fly   707 FYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQW----AETDYSTQWCYENFI----------- 756
            .||..:.:    ..|.:.....||..:|:.::.:|    |....:.:|..||.|
 Worm   611 SYRELEIV----ERRASLTSPLGDPFTLISIFREWVLQKAFEGTARRWTMENGIDEHRLYEISKL 671

  Fly   757 --QYRSM---------------------------------------KRARDVREQLVGLMQ---- 776
              |||.:                                       :|..|.|::::...:
 Worm   672 RAQYRQILEDAGLVEKASAAETGEDDSRQRRIDQGEKRKLFDLKKSQRNNDRRQKVLNANKHFDK 736

  Fly   777 ----------RVEIDMVSCLPETV------------NVRKA--------------ATAGYFYHVA 805
                      ..|.|.:....:||            |:||.              ..||.:.:.:
 Worm   737 ILEDKEEEDLEAEKDPLKADVKTVEFLLSHKQRDVENIRKTHKISRKTAEVVRVIIAAGLYPNFS 801

  Fly   806 RLSKGGHY----KTIKHNQT---VMIHPNSSL----------------FEELPRWVLYHELVFTS 847
            .|.....|    :...|.:.   ..||||||:                |..|.:...|..|:.|:
 Worm   802 ILDPVNKYGYGQEMFTHTRLKPFTQIHPNSSIAQYHPETIDPRQGSDGFSRLHQIPFYGLLLETT 866

  Fly   848 KEYMRQVIEIESKWLLEVA 866
            |.|:..|:.:.:.:.|.||
 Worm   867 KPYICNVMPVPAVYTLLVA 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	27/179 (15%)
		HrpA	251..>868	CDD:441249	228/765 (30%)
smgl-2	NP_001294374.1	HrpA	143..>694	CDD:441249	196/572 (34%)
		OB_NTP_bind	788..888	CDD:400182	22/98 (22%)