DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and ddx-35

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	297/729 - (40%)
Similarity:	436/729 - (59%)	Gaps:	50/729 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 EAEQLASARFHFGAKD--AKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERK---- 241
            |..:.|.||..|...|  |.|.....|:.:::           |.|.:.:..|  .|::.|
Worm    12 EPRKGAGARRGFARPDDSADAPRTGPLIFEER-----------STENAGAAPP--IEEQLKVHNN 63

  Fly   242 ---RLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGC 303
               .|.:.:.|..||::..:..::...:.::.:||.||||.||:|||||:|:|||:..|.:.|..
Worm    64 PYASLNIQQQRIRLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVI 128

  Fly   304 TQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYS 368
            |||||||.:::|.|||||....||::|||::||:|.:...|.:|:||||.|.||.|::|.|:.||
Worm   129 TQPRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYS 193

  Fly   369 VMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFF----------DDAPIF 423
            :::|||||||:.:||||.||::.|.:.|.:|::::||||||||.|..||          |.|.|.
Worm   194 IIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAELFKDFFEMNETGNSDKDTAGII 258

  Fly   424 RIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRL 488
            .:.||.:||.:.:||....||..:...:|:.||..:..||||||||||||:|...|.|.:....|
Worm   259 SVEGRTHPVAVHHTKTSVPDYCQSAVDTVINIHKHENPGDILVFLTGQDEVEDVCEKLRELAGNL 323

  Fly   489 GSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNF 553
            .:..| |.|:|.|..||:..|.|.|:.||...|||::||||||.|:||..|.||||.|:.|....
Worm   324 KNCDR-LWVVPCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQ 387

  Fly   554 NSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVL 618
            ::..|:|:||.|.:|||||.||||||||..||||:|||....:: ...:.|||||||..:.:.:|
Worm   388 HAANGVETLMRVTVSKASAEQRAGRAGRIRPGKCYRLYPESEFE-RFAEGTVPEIQRCQMASTIL 451

  Fly   619 MLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTK-LGRRMAEFPVDPMMGKMLL 682
            .|||||:.::..|.:|.|||...::..||.||||||::...:||. ||.:|||||:.||..|.||
Worm   452 QLKALGVQNVHRFHYLSPPPSWAMINGLELLYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLL 516

  Fly   683 ASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYS 747
            .|.::.||.|||||.||:.:.. :|..|..:...||..||.|....|||:::|.|:.::.|...|
Worm   517 KSAEFGCSTEMVTIVAMMQIQD-VFITPYRQRHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRS 580

  Fly   748 TQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVS------CLPETVNVRKAATAGYFYHVAR 806
            .:||.::|:.||.:.||.:||.|||.|::|.||:.||      |   :.|:|:....|:|...|:
Worm   581 KKWCSDHFVNYRGLMRADNVRSQLVRLLKRFEIEKVSSRGLINC---SENIRQCLVTGFFSQAAQ 642

  Fly   807 LSKGGHYKTIKHNQTVMIHPNSSLF--EELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHY 869
            ....|.|.|:|.:....::..||:.  ::.|:||::.|::   ::.:|.|..||.:||.|:||||
Worm   643 YHYTGKYMTVKESFPFNMYKGSSIMFKKDYPKWVIFTEVM---QDSIRDVTVIEPEWLYELAPHY 704

  Fly   870 YKAKELEDSTNKKM 883
            |:.....:...|:|
Worm   705 YEFGTEGELAEKRM 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	281/670 (42%)
		DEXDc	269..408	CDD:238005	73/138 (53%)
		HELICc	491..581	CDD:197757	47/89 (53%)
		HA2	651..735	CDD:214852	38/84 (45%)
		OB_NTP_bind	770..869	CDD:285018	34/106 (32%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	275/640 (43%)
		DEXDc	96..233	CDD:238005	73/136 (54%)
		Helicase_C	284..416	CDD:278689	67/132 (51%)
		HA2	484..568	CDD:214852	38/84 (45%)
		OB_NTP_bind	602..704	CDD:285018	34/107 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730