DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and mog-4

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_497027.1	Gene:	mog-4 / 175117	WormBaseID:	WBGene00003392	Length:	1008	Species:	Caenorhabditis elegans

Alignment Length:	915	Identity:	596/915 - (65%)
Similarity:	728/915 - (79%)	Gaps:	49/915 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KN-RKRTASSSSSGEEP----------------DSEE-----ESRL-KDLQERDEFASRLKKRDD 45
            || |||..|||...|.|                |||.     |::| .|:.|||..|:|:.|::.
Worm   109 KNVRKRKESSSEDDEAPIKASKPGKSVKPSKSDDSESDIEAMEAKLDADIAERDALAARINKKEK 173

  Fly    46 DRTRNVVDSTGGRRAIEEATKRLKLEHEDRDK---IVPHLRLQSRRQYLEKRKDDKVAELEADIL 107
            |:||||::               |...:::||   .:..||.:||||||:|||.||:.||||.:.
Worm   174 DKTRNVME---------------KKRDDNKDKEGSSMDKLREESRRQYLKKRKVDKLEELEAIVH 223

  Fly   108 DDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFE 172
            ||:.||....||||||.:.||:|::|...|.|.||.::.:::||::|....|...|:|||.||.:
Worm   224 DDQTLFAREKLTKREKADMEYRKKVLEYTKAHGKAGDVMKMKRYHLPDASTKQIPSQYVEDDEED 288

  Fly   173 KQPNSEQKKWEAEQLASARFHFGAKDAK-AEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELT 236
            .:|..:..|||.|||.::..|.|||||| .|:|:|||||:::||||||.:.|:.|:...     |
Worm   289 FRPGGDGAKWEEEQLMASMLHLGAKDAKRKEQEFELLLDEKVDFIQALQMPGTNEEVVE-----T 348

  Fly   237 EKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMI 301
            |.|:|:::::|||:|||||.|::..|.|||||||||||||||||||||:||||.||||.:..|.|
Worm   349 EAEKKKMSIEETRKSLPVYAFRDAFIEAVKEHQVLIIEGETGSGKTTQLPQYLYEAGFCEGGKRI 413

  Fly   302 GCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLAS 366
            ||||||||||||||||||:|:|.|||.:||||||||||||::|:|||||||.|.||||:||||||
Worm   414 GCTQPRRVAAMSVAARVADEVGCKLGTQVGYSIRFEDCTSEKTVLKYMTDGMLLREFLNEPDLAS 478

  Fly   367 YSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYP 431
            ||||:|||||||||||||||||||||||||.:||||||||||||||||:||||||||||||||:|
Worm   479 YSVMMIDEAHERTLHTDILFGLVKDIARFRKDLKLLISSATLDAEKFSSFFDDAPIFRIPGRRFP 543

  Fly   432 VDIFYTKAPEADYIDACCVSVLQIHATQPL-GDILVFLTGQDEIETCQEVLHDRVKRLGSKIREL 495
            |||:||:||||||:||..|:::|||.|||| ||||||||||:||||.||.|.:|.|.|||||:||
Worm   544 VDIYYTQAPEADYVDAAIVTIMQIHLTQPLPGDILVFLTGQEEIETVQEALMERSKALGSKIKEL 608

  Fly   496 IVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGME 560
            |.:|||||||||:|||||||||.:||||:|||||||||:|||.|.|||||||:|||:|::|:|:|
Worm   609 IPLPVYANLPSDLQAKIFEPTPKDARKVVLATNIAETSVTIDGINYVIDPGFSKQNSFDARSGVE 673

  Fly   561 SLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGI 625
            .|.||.||||:|||||||||||.||||||||||||||||||:..:|||||.||||.|||||:|||
Worm   674 HLHVVTISKAAANQRAGRAGRTGPGKCFRLYTAWAYKHELEEQPIPEIQRTNLGNVVLMLKSLGI 738

  Fly   626 NDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCS 690
            :||:|||||||||.||||:|||||||||||||.||||||||||||||.||.|.||::|||||:||
Worm   739 HDLVHFDFLDPPPQETLVIALEQLYALGALNHRGELTKLGRRMAEFPCDPCMSKMIIASEKYECS 803

  Fly   691 EEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENF 755
            ||:||||||||.|:|:|||||.::||||:|||.|....|||::|:.|||:|.|:.:|.:||.||:
Worm   804 EEIVTIAAMLSCNAAVFYRPKAQVIHADSARKGFWSPAGDHITLMNVYNKWQESSFSQRWCVENY 868

  Fly   756 IQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQ 820
            :|:|:||||||||:|||||::||||:..|. .:|:.:|||.||||||:|::|...|||||:||..
Worm   869 VQHRTMKRARDVRDQLVGLLERVEIETKSS-TDTIKIRKAITAGYFYNVSKLDNTGHYKTVKHKH 932

  Fly   821 TVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELEDSTNKKMPK 885
            |...||||.||||.||||:|.||||||||:||::.||||.|||||||||||.:||||:|||||||
Worm   933 TTHPHPNSCLFEETPRWVVYFELVFTSKEFMREMSEIESGWLLEVAPHYYKGRELEDATNKKMPK 997

  Fly   886 VAGRA 890
            ..|::
Worm   998 NKGKS 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	476/645 (74%)
		DEXDc	269..408	CDD:238005	117/138 (85%)
		HELICc	491..581	CDD:197757	69/89 (78%)
		HA2	651..735	CDD:214852	61/83 (73%)
		OB_NTP_bind	770..869	CDD:285018	64/98 (65%)
mog-4	NP_497027.1	DTHCT	<103..162	CDD:285332	17/52 (33%)
		DEXDc	370..546	CDD:214692	147/175 (84%)
		DEXDc	381..520	CDD:238005	117/138 (85%)
		Helicase_C	577..696	CDD:278689	91/118 (77%)
		HA2	764..848	CDD:214852	61/83 (73%)
		OB_NTP_bind	872..981	CDD:285018	73/109 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162654
Domainoid	1	1.000	511	1.000	Domainoid score	I160
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2658
Inparanoid	1	1.050	1163	1.000	Inparanoid score	I106
Isobase	1	0.950	-	0	Normalized mean entropy	S654
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto18230
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R178
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.850