DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and rha-1

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_495890.2	Gene:	rha-1 / 174417	WormBaseID:	WBGene00004355	Length:	1301	Species:	Caenorhabditis elegans

Alignment Length:	1012	Identity:	255/1012 - (25%)
Similarity:	436/1012 - (43%)	Gaps:	221/1012 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TASSSSSGEEPDSEEESRLKDLQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLE-H 72
            ||:....||:.:|.:||:....|:|..:::...:|::......:.......|..| |..||.| |
Worm   101 TATMFCGGEDGNSFQESQQPIPQKRFPWSNNAYQRNEGTHEQYITQKAEEIAASE-TVDLKSEIH 164

  Fly    73 -----EDRDKIVPHLRLQSRR----QYLEKRKDD---KVAELEADILDDEYLFDESVLTKREKEE 125
                 |:..|.:... ||..|    .|..|.::.   |..|..|.|...:  .:::::.|.....
Worm   165 GGWTMENSKKALNEF-LQKMRLPQVNYGTKIRESNTVKTMETTAQIFVPQ--INKNLVGKGTGSN 226

  Fly   126 REYK---------KQL--LNIAKEH------EKARELERIQRYNMPQDLKKGERSEYV------- 166
            ::..         :|:  |||.:.:      .|...|..| ..::|:||.. ..:|||
Worm   227 KKVSEAACAMNIVRQMFHLNIMQSYSGPIKKSKVSTLPEI-AISIPEDLST-RVTEYVRSCGLEL 289

  Fly   167 -EVDEFEKQPNS--------EQKKWEAEQLASARFHFGA---------KDAKAEEEYELLLDDQI 213
             |::|....|.:        :..::...::.||.....|         :.:..:||       .:
Worm   290 PEINETSATPEAPTSLLTDVKLAQFPVSEICSASNISWAPPLQNWNPWRASNIDEE-------PL 347

  Fly   214 DFIQALTLDGSREKSSSRQPELTEKE--RKRLTLDE---TRRSLPVYPFKEDLIAAVKEHQVLII 273
            .|:       |.|:.|.|   :.|||  ::...||:   .|..|||..::|:::..|.|::|.:|
Worm   348 AFM-------SMEQISQR---IMEKEDFKRGEALDKITAQRGELPVAQYRENIVQTVAENRVTLI 402

  Fly   274 EGETGSGKTTQVPQYLVEAGFTKDKKMIG----CTQPRRVAAMSVAARVAEEMGVKLGNEVGYSI 334
            :||||.||:|||.|:|:|: |.::.....    .:||||::|:|:|.|||.|.|.::|...||::
Worm   403 KGETGCGKSTQVAQFLLES-FLENSNGASFNAVVSQPRRISAISLAERVANERGEEVGETCGYNV 466

  Fly   335 RFEDCT-SDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPE 398
            ||:..| .....:.:.|.|.|.|  :.|..|...|.:||||.|||.:.||.:..:::::.....:
Worm   467 RFDSATPRPYGSIMFCTVGVLLR--MMENGLRGISHVIIDEIHERDVDTDFVLIVLREMISTYRD 529

  Fly   399 LKLLISSATLDAEKFSAFFDD------APIFRIPGRRYPVDIFY--------------------- 436
            |::::.|||:|.:.|:.||..      .|:..:.||.:||..||
Worm   530 LRVVLMSATIDTDLFTNFFSSIPDVGPTPVITMHGRTFPVQSFYLEDILHNLQHMPEEPDQKKRK 594

  Fly   437 ---------------------------------------TKAPEADYIDACCVSVLQIHATQPL- 461
                                                   ::..|.|.......::|...|::.:
Worm   595 KGGPPPPDDDEGDEEVDDKGRNMNILTDPSINESLKTAMSRISEKDIPFGVIEAILNDIASRGVD 659

  Fly   462 GDILVFLTGQDEIET-CQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVIL 525
            |.:||||.|..||.| |..:|..:.....:|..   ::|:::.|.|..|.|:|... |..||:|:
Worm   660 GAVLVFLPGWAEIMTLCNRLLEHQEFGQANKYE---ILPLHSQLTSQEQRKVFNHY-PGKRKIIV 720

  Fly   526 ATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRL 590
            :|||||||:|||:::||||...||:..:.|...|.....|..||.:..||.|||||...|..|.|
Worm   721 STNIAETSITIDDVVYVIDSCKAKERMYTSNNNMVHFATVWASKTNVIQRRGRAGRVRAGYAFHL 785

  Fly   591 YTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHF--DFLDPPPHETLVLALEQLYALG 653
            .:...:: .|:|:...|:.||.|....|.:|.|.:..:..|  ..|.|||::.:|.:...|.|:|
Worm   786 CSKMRFE-ALDDHGTAEMLRIPLHQIALTIKLLRLGSVGEFLGKALQPPPYDMVVESEAVLQAMG 849

  Fly   654 ALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHAD 718
            ||:.:.|||.||:.:|..|::|::.|:|:..........|..:|:.:|..:....|.|.....:.
Worm   850 ALDRNLELTSLGKMLARMPIEPVIAKVLILGTALGAGSVMCDVASAMSFPTPFVPREKHHSRLSG 914

  Fly   719 TARKNFNHMHGDHLSLLQVYNQW----------AETDYSTQWCYENFIQYRSMKRARDVREQLVG 773
            |.||...:...||::::.|...:          ||.::..::...|.:    :|.....|.||:.
Worm   915 TQRKFAGNKFSDHVAIVSVIQGYREAVQMGASAAEREFCERYSLSNPV----LKMTDGARRQLID 975

  Fly   774 LMQRVEIDMVSC-LPE------TVNV----------RKAATAGYFYHVARLSKGGHYKTIKHNQT 821
            :::.      .| .||      :|||          |.......:.:||      :|  :...:.
Worm   976 VLRN------QCSFPEDILFDISVNVNGPDRELNLMRSLLVMALYPNVA------YY--VGKRKV 1026

  Fly   822 VMIHPNSSLFEELPRWVLYHE----------LVFTSK 848
            :.|..:|:|..:....|..:.          ||||.|
Worm  1027 LTIEQSSALINKYSMLVPMNNRQEMDFPSPLLVFTEK 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	204/744 (27%)
		DEXDc	269..408	CDD:238005	52/143 (36%)
		HELICc	491..581	CDD:197757	37/89 (42%)
		HA2	651..735	CDD:214852	24/83 (29%)
		OB_NTP_bind	770..869	CDD:285018	21/106 (20%)
rha-1	NP_495890.2	DSRM	6..71	CDD:214634
		DSRM	173..243	CDD:214634	12/72 (17%)
		HrpA	337..>974	CDD:224557	187/665 (28%)
		DEXDc	398..539	CDD:238005	52/143 (36%)
		Helicase_C	649..739	CDD:278689	36/93 (39%)
		HA2	847..931	CDD:214852	24/83 (29%)
		OB_NTP_bind	971..1086	CDD:285018	21/107 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810