Protein Alignment l(2)37Cb and mog-5

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_495019.1
• Gene: mog-5 / 173920
• WormBaseID: WBGene00003393
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1035
• Identity: 444/1035 - (42%)
• Similarity: 619/1035 - (59%)
• Gaps: 163/1035 - (15%)

  Fly     2 SGKNRKRTAS--------SSSSGE-----EPDSEEESRLKDLQERDEFASRLK--KRDDDRTRNV 51
            |.:||.|:.|        .|.||:     ...|.|:.|.:|.::||....|.:  :|.|||.|:.
 Worm   152 SKRNRSRSRSRSRDRKRRRSRSGDRDRRRRSRSREDRRDRDRRDRDRDRDRGRGDRRGDDRQRDR 216

  Fly    52 VD--STGGRRAIEEATKRLKLEHEDRDKIV----PHLRLQSRRQ------YLEKRKDDKVAELEA 104
            .|  ..||.|..|.|  .:...::.|...:    ..:.|:..||      ::.:.::::| :..|
 Worm   217 RDRRDDGGARKSEVA--EIGKIYDGRVNSIQSFGAFITLEGFRQKQEGLVHISQIRNERV-QTVA 278

  Fly   105 DILDDEYLFDESVLTKREKEER-----------EYKKQLLNIAKEHE------------------ 140
            |:|..    .|:|..|..|.|.           :...:.|| .:|.:
 Worm   279 DVLKR----GENVKVKVNKIENGKISLSMKEVDQNSGEDLN-PRETDLNPDAIGVRPRTPPASTS 338

  Fly   141 ---------------------KAR---------ELERIQ------RYNMPQ-DLKKGERSEY--- 165
                                 |||         ||.::|      ..:||. |.:.|....|
 Worm   339 SWMNPEASGVGQGPSTSIGGGKARVRISTPERWELRQMQGAGVLTATDMPDFDEEMGVLRNYDDE 403

  Fly   166 -----VEVDEFEKQPN--SEQKKWEAE------------QLASARFHFGA-----KDAKAEEEYE 206
                 :|::..|.:|:  ....|..||            .||.|....||     |:.|.:.:.|
 Worm   404 SDGEDIEIELVEDEPDFLRGYGKGGAEIEPVKVVKNPDGSLAQAALMQGALSKERKETKIQAQRE 468

  Fly   207 LLLDDQIDFIQ--------------ALTLDGSREKSS--SRQPE----------LTEKERKRLTL 245
            ..:|.|..|..              |.:.|.|:::::  ...||          .|...|..|::
 Worm   469 RDMDTQKGFSSNARILDPMSGNQSTAWSADESKDRNNKMKEMPEWLKHVTAGGKATYGRRTNLSM 533

  Fly   246 DETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVA 310
            .|.|.|||::..|::|:.|:.::|:|::.||||||||||:.||.:|||..:..| ||||||||||
 Worm   534 VEQRESLPIFALKKNLMEAMIDNQILVVVGETGSGKTTQMTQYAIEAGLGRRGK-IGCTQPRRVA 597

  Fly   311 AMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEA 375
            |||||.|||||.|.|||.:|||:||||||||..||:||||||.|.||.|.:|||:.||::::|||
 Worm   598 AMSVAKRVAEEYGCKLGTDVGYTIRFEDCTSQDTIIKYMTDGMLLRECLIDPDLSGYSLIMLDEA 662

  Fly   376 HERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAP 440
            ||||:|||:||||:|..||.||||||:|:|||||:.|||.:|.:||||.||||.:||:|.||:.|
 Worm   663 HERTIHTDVLFGLLKAAARKRPELKLIITSATLDSVKFSEYFLEAPIFTIPGRTFPVEILYTREP 727

  Fly   441 EADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLP 505
            |:||::|..::|:|||.|:|.||:|||||||:||:|..|||::|:|.:|..:.|||::|||..||
 Worm   728 ESDYLEAAHITVMQIHLTEPPGDVLVFLTGQEEIDTSCEVLYERMKSMGPDVPELIILPVYGALP 792

  Fly   506 SDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKA 570
            |:||.:||:|.|...|||::||||||||||||.|.||:||||.||..:|.::||:||:|.|||:|
 Worm   793 SEMQTRIFDPAPAGKRKVVIATNIAETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPISQA 857

  Fly   571 SANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLD 635
            :|.||:||||||.||||:||||..|::.|:....||||||.||.:.:|.|||:|||:||.|||:|
 Worm   858 AAKQRSGRAGRTGPGKCYRLYTERAFRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDFDFMD 922

  Fly   636 PPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAML 700
            .||.::::.||..|:.|.||:..|.||||||||||||::|.:.|:|:.|....||||::||.|||
 Worm   923 APPLDSMITALNTLHTLSALDGDGLLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAML 987

  Fly   701 SVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRAR 765
            :|.: ||||||:|..|||..:..|:...||||:||.|||.|....:|..||:|||||.||||||:
 Worm   988 NVQN-IFYRPKEKQDHADQKKAKFHQPEGDHLTLLAVYNSWKNHHFSQPWCFENFIQVRSMKRAQ 1051

  Fly   766 DVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSL 830
            |:|:||:|:|.|.::.||||..:...|:||..:|:|.:.|:......|:|:...|.|.|||:|:.
 Worm  1052 DIRKQLLGIMDRHKLLMVSCGRDVSRVQKAICSGFFRNAAKRDPQEGYRTLTDGQNVYIHPSSAC 1116

  Fly   831 FEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELEDSTN----KKMPKV 886
            |::.|.||:|||||.|:|||||:|..|:.|||:|.||.::|   :.|||.    |:..|:
 Worm  1117 FQQQPEWVVYHELVMTTKEYMREVTAIDPKWLVEFAPSFFK---IGDSTKLSTFKRNQKI 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	84/406 (21%)
		HrpA	251..>868	CDD:441249	357/616 (58%)
mog-5	NP_495019.1	GH2-like_DHX8	4..73	CDD:409668
		S1_DHX8_helicase	234..311	CDD:240189	13/81 (16%)
		HrpA	538..>1157	CDD:441249	358/620 (58%)