DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and let-355

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_491604.3	Gene:	let-355 / 172199	WormBaseID:	WBGene00020263	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	829	Identity:	270/829 - (32%)
Similarity:	416/829 - (50%)	Gaps:	102/829 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 EHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDAKAE 202
            :.:|.:.||.:::..|....||             ||.|:.||:   |:|.|:.|.......|.|
Worm    53 QEQKFQNLEALKKKTMLLKKKK-------------KQMNNFQKE---EELLSSTFRITNGILKKE 101

  Fly   203 EEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRR----------------- 250
            ::           |:..|:.....|...:.|..|....|..|...||:
Worm   102 KK-----------IEVTTISTQTPKKLPKTPISTPSNSKNATPMSTRKHSSSQQSPPHFEANYEK 155

  Fly   251 ----SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAA 311
                .||:...::.|:..:...:.||:.|||||||:|||||..|.||.. :...|..||||||||
Worm   156 FSRPQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIA-NSGSIAVTQPRRVAA 219

  Fly   312 MSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAH 376
            :|:|:|||.|||..:|..|||.:|||:.|..:|.::|||||.:.|:.|..|.|..||.:||||||
Worm   220 ISLASRVATEMGTNIGGIVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAH 284

  Fly   377 ERTLHTDILFGLVKDIARFRPE----LKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYT 437
            ||:||:|:|..:::.....|.|    |:|:|.||||.||||.::|::|.:..:.||.:|:::|:.
Worm   285 ERSLHSDVLMCILRQCQDQRRETNNPLRLIIMSATLQAEKFQSYFNNAKVVLVAGRTFPIEVFHV 349

  Fly   438 KA------PEADYIDACCVSVLQIHATQPLG-DILVFLTGQDEIETCQEVLHDRVKRLGSKIREL 495
            ..      ...||:....:.|..:|.|:|.| ||||||||.:|||.....|.:....|.:....|
Worm   350 NPKINKSFSSTDYVYNAVICVKYVHLTEPKGRDILVFLTGSEEIEAVASQLAELNGSLPASADVL 414

  Fly   496 IVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGME 560
            :.:|:||.|..:.|.:.|..||..|||||::|||||||:||..|..|||.|..|...|.:...::
Worm   415 MPVPLYAALRPEKQKEAFRKTPQGARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRID 479

  Fly   561 SLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGI 625
            .|.|..:|||.|.||||||||.|||||:|||:...: |:.|...:|||.|.||....|.|..||:
Worm   480 VLKVHNVSKAQAKQRAGRAGRDAPGKCYRLYSREDF-HKFEAENMPEILRCNLSATFLELMKLGM 543

  Fly   626 NDLIHFDFLDPPPHETLVLALEQLYALGALNHHGE------LTKLGRRMAEFPVDPMMGKMLLAS 684
            .:......:|||..:.:..||.:|.:|||:.....      ||::|.....:|:.|...::|..:
Worm   544 KNPHRLKLIDPPETDNINAALLELTSLGAIRPVNSDRSKFALTEMGDAFCMYPLPPDHARILFQA 608

  Fly   685 EKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADT--ARKNFNHMHGDHLSLLQ---VYNQW--- 741
            :|..|..|.:.|.|.:..: |:|....|....||.  .|:.|....|||::||:   |.||:
Worm   609 QKEGCIMEAIKIVAAMQTD-ALFSGAGDSKSDADVDRIRRRFETREGDHITLLKLVLVTNQFFDQ 672

  Fly   742 -----------------AETDYS---TQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCL 786
                             .|.:|:   .::|.:|.|..:.:|.|..:.|||..:....::...:|.
Worm   673 LNKKTESDARYGKANKSLEREYNQTIRKFCNDNMINEQHLKTASMIEEQLKQIAIEQKVTFSTCG 737

  Fly   787 PETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQ--TVMIHPNSSLFEELPRWVLYHELVFTSKE 849
            .:.:.:|||...|.|.:.....:......:..|.  |:.|||:|.|....|.::::.||:.|:..
Worm   738 ADFMKMRKALALGMFLNSCEYDRQEDRYRLMINPAITLKIHPSSCLSRSKPAYIVFSELMKTNDL 802

  Fly   850 YMRQVIEIESKWLLEVAPHYYK--AKELEDSTNK--KMPKVAGRAEMAQ 894
            :..||..|:..|:..:...:.|  |..|.::|.:  ::.::..:|:.|:
Worm   803 FALQVTLIDGDWVRPLISDHKKMRANHLAETTERVQQITRLEPKAKKAK 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	245/712 (34%)
		DEXDc	269..408	CDD:238005	73/142 (51%)
		HELICc	491..581	CDD:197757	42/89 (47%)
		HA2	651..735	CDD:214852	24/91 (26%)
		OB_NTP_bind	770..869	CDD:285018	23/100 (23%)
let-355	NP_491604.3	HrpA	149..>800	CDD:224557	233/653 (36%)
		DEXDc	180..320	CDD:238005	73/140 (52%)
		Helicase_C	383..500	CDD:278689	54/116 (47%)
		HA2	569..660	CDD:214852	24/91 (26%)
		OB_NTP_bind	712..822	CDD:285018	26/109 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830