DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)37Cb and DHX36

DIOPT Version :9

Sequence 1:NP_609946.1 Gene:l(2)37Cb / 35192 FlyBaseID:FBgn0086444 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens


Alignment Length:911 Identity:273/911 - (29%)
Similarity:429/911 - (47%) Gaps:193/911 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 EHEDRDKIVPHLRLQSRRQYLE-----KRKDDKVAELEADI---LDDEYLFDESVLTKR----EK 123
            |.|.:::.|.|:..:...|.::     :.|:||  |.||.|   ..:::.:...|.||.    |.
Human    76 EAERQERAVVHMDERREEQIVQLLNSVQAKNDK--ESEAQISWFAPEDHGYGTEVSTKNTPCSEN 138

  Fly   124 EEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQLA 188
            :....:|:|:|..|:..:.|....|.|           .|||: :.|.|.....:||        
Human   139 KLDIQEKKLINQEKKMFRIRNRSYIDR-----------DSEYL-LQENEPDGTLDQK-------- 183

  Fly   189 SARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLP 253
                               ||:|.           .::|:..|..|          :...|..||
Human   184 -------------------LLEDL-----------QKKKNDLRYIE----------MQHFREKLP 208

  Fly   254 VYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKK---MIGCTQPRRVAAMSVA 315
            .|..:::|:..:..|||.:|.||||.||||||.|::::....:.|.   .|.||||||::|:|||
Human   209 SYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVA 273

  Fly   316 ARVAEEMGVKL--GNEVGYSIRFEDCTSDR--TILKYMTDGTLHREFLSEPDLASYSVMIIDEAH 376
            .|||.|.....  ||..||.||.:.....:  :|| |.|.|.:.:...|:|.|:|.|.:::||.|
Human   274 ERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSIL-YCTTGIILQWLQSDPYLSSVSHIVLDEIH 337

  Fly   377 ERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTK--- 438
            ||.|.:|:|..:|||:..||.:||:::.||||:|||||.:|.:.|:..|||..:||..:..:   
Human   338 ERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVI 402

  Fly   439 -----APE---------------------------------ADYI-------DACCVSVLQIHAT 458
                 .||                                 .||:       .|..|.|:::...
Human   403 EKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPDYVRELRRRYSASTVDVIEMMED 467

  Fly   459 QPL------------------GDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLP 505
            ..:                  |.|||||.|.|.|.|..::|..:|.   .|..:.::||:::.:|
Human   468 DKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVM---FKSDKFLIIPLHSLMP 529

  Fly   506 SDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKA 570
            :..|.::|:.|||..||:::||||||||:|||:::||||.|..|:.:|:::..:.::....:|||
Human   530 TVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKA 594

  Fly   571 SANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHF--DF 633
            :|.||.|||||..||.|:.||.. .....|:|..:|||.|..|....|.:|.|.:..:.:|  ..
Human   595 NAKQRKGRAGRVQPGHCYHLYNG-LRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRL 658

  Fly   634 LDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAA 698
            :|||.:|.::|::..|..|.||:...|||.||..:|..||:|.:|||:|....:.|.:.::||||
Human   659 MDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAA 723

  Fly   699 MLSVNSAIFYRP--KDKIIHADTARKNF-NHMHGDHLSLLQVYNQWAET-----DYSTQWCYENF 755
            .||.... |..|  |:||  ||..||.. .....|||:::..:..|.|.     .|...:|:|.|
Human   724 SLSFKDP-FVIPLGKEKI--ADARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDYCWEYF 785

  Fly   756 IQYRSMKRARDVR----EQLVG---LMQRVEIDMVSCLPET-VN------VRKAATAGYFYHVA- 805
            :...:::...:::    |.|:|   :..|...|     ||: :|      ::....||.:..|| 
Human   786 LSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKD-----PESNINSDNEKIIKAVICAGLYPKVAK 845

  Fly   806 -RLSKGGHYKTIK-HNQT---VMIHPNSSLFEELP---RWVLYHELVFTSKEYMRQVIEIESKWL 862
             ||:.|...|.:| :.:|   |.:||.|...|:..   .|::||..:.||..|:....|:....|
Human   846 IRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL 910

  Fly   863 L 863
            |
Human   911 L 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)37CbNP_609946.1 HrpA 222..867 CDD:224557 240/748 (32%)
DEXDc 269..408 CDD:238005 63/145 (43%)
HELICc 491..581 CDD:197757 38/89 (43%)
HA2 651..735 CDD:214852 35/86 (41%)
OB_NTP_bind 770..869 CDD:285018 31/113 (27%)
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 36/185 (19%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 5/28 (18%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 108/342 (32%)
DEXDc 210..392 CDD:214692 78/182 (43%)
DEXDc 224..369 CDD:238005 63/145 (43%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 21/52 (40%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 70/244 (29%)
Helicase_C 476..606 CDD:278689 51/132 (39%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 22/61 (36%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 2/10 (20%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 24/68 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 19/58 (33%)
HA2 676..760 CDD:214852 35/86 (41%)
OB_NTP_bind 800..917 CDD:285018 32/117 (27%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 19/63 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 3/10 (30%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 10/29 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53574
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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