Protein Alignment l(2)37Cb and DHX15

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001349.2
• Gene: DHX15 / 1665
• HGNCID: 2738
• Length: 795
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 344/641 - (53%)
• Similarity: 448/641 - (69%)
• Gaps: 27/641 - (4%)

  Fly   249 RRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE--AGFTKDKKMIGCTQPRRVAA 311
            |..|||:.:|:.....:..||..::.||||||||||:||:.||  ......|:.:.|||||||||
Human   134 RLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAA 198

  Fly   312 MSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAH 376
            ||||.|||:||.|.||.|||||||||||:|.:|||||||||.|.||.:::|.|..|.|:|:||||
Human   199 MSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAH 263

  Fly   377 ERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPE 441
            ||||.||||.|::|::.|.|.:||:::.||||||.||..:||:.|:..||||.:||:||||..||
Human   264 ERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPE 328

  Fly   442 ADYIDACCVSVLQIH-ATQPLGDILVFLTGQDEI-ETCQEVLHDRVKR----LGSKIRELIVIPV 500
            .||::|...:|:||| ..:..||:|:|||||:|| |.|:     |:||    ||.::.::.:||:
Human   329 RDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACK-----RIKREVDDLGPEVGDIKIIPL 388

  Fly   501 YANLPSDMQAKIFEPTPPN------ARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGM 559
            |:.||...|.:||||.||.      .|||:::|||||||||||.:::|||||||||..:|.|..:
Human   389 YSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRV 453

  Fly   560 ESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALG 624
            |||:|..||||||.|||||||||.|||||||||..|||.|::|||.|||.|.|||:.||.||.||
Human   454 ESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLG 518

  Fly   625 INDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKC 689
            |:||:||||:|||..|||:.|||.|..|.|||..|:||:||..|||||:||.:.||::||..|.|
Human   519 IDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNC 583

  Fly   690 SEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYEN 754
            |.|:::|.|||||... |.||.:....||.|:..|.|:.||||:||.||:.:.:...|.||||:|
Human   584 SNEVLSITAMLSVPQC-FVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDN 647

  Fly   755 FIQYRSMKRARDVREQLVGLMQRVEI-----DMVSCLPETVNVRKAATAGYFYHVARLSKGGHYK 814
            ||.|||:..|.:||:||..:|.|..:     |..| ....:|:|||...|||..||.|.:.|||.
Human   648 FINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTS-RDYYINIRKALVTGYFMQVAHLERTGHYL 711

  Fly   815 TIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYY 870
            |:|.||.|.:|| |::.:..|.||||:|.|.|:|.|:|...:|:.:||:::||.||
Human   712 TVKDNQVVQLHP-STVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYY 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	5/17 (29%)
		HrpA	251..>868	CDD:441249	340/635 (54%)
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108
		HrpA	136..>763	CDD:441249	339/634 (53%)
		DEAH box	260..263		2/2 (100%)