DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)37Cb and DHX9

DIOPT Version :9

Sequence 1:NP_609946.1 Gene:l(2)37Cb / 35192 FlyBaseID:FBgn0086444 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:914 Identity:245/914 - (26%)
Similarity:405/914 - (44%) Gaps:187/914 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGKNRKRTASSSSSGEEPDSEEESRLKDL---QERDEFASRLKKRDDDRTRNVVDSTGGRRAIE 62
            :..:|.....:|......|..:..:.|||.   :|..|..:.|:..:.|....:    .|...:|
Human   119 LKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGL----HGNWTLE 179

  Fly    63 EATKRLKLEHEDRDKI---------------------VPHLRLQSRRQYLEKRKDDKVAELEADI 106
            .|..||. ::..::||                     ..:::...||.:..:...:|....::..
Human   180 NAKARLN-QYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCA 243

  Fly   107 LD-----------DEYLFDESVLTKREKEE--REYKKQLLNIAKEHEKARELER-IQRYNM---- 153
            |.           :.|    |.|||:::.|  ..||   :|::::.|  .:|:. ||..|:    
Human   244 LSLVRQLYHLGVVEAY----SGLTKKKEGETVEPYK---VNLSQDLE--HQLQNIIQELNLEILP 299

  Fly   154 -PQD------LKKGERSEYVEVDEFEKQ--------PNSEQKKWEAEQLASARFHFG-----AKD 198
             |:|      |..|:.::: |..:.:.|        |.|....|.:..:......|.     :.|
Human   300 PPEDPSVPVALNIGKLAQF-EPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMD 363

  Fly   199 AKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIA 263
            .|.|..|:|                  |:....|..|.|:|           .|||..|:.:::.
Human   364 LKNELMYQL------------------EQDHDLQAILQERE-----------LLPVKKFESEILE 399

  Fly   264 AVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGC----TQPRRVAAMSVAARVAEEMGV 324
            |:.::.|:||.|.||.||||||||:::: .|.::.:...|    |||||::|:|||.|||.|.|.
Human   400 AISQNSVVIIRGATGCGKTTQVPQFILD-DFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGE 463

  Fly   325 KLGNEVGYSIRFED-CTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGL 388
            :.|...|||:|||. .......:.:.|.|.|.|:.  |..:...|.:|:||.|||.::||.|..:
Human   464 EPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVV 526

  Fly   389 VKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTK---------APEADY 444
            ::|:.:..||:::::.|||:|...|..:|.:.||..:.||.|||..::.:         .|..|.
Human   527 LRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDK 591

  Fly   445 ------------IDACC-------------VSVLQIHATQ-PL----------------GDILVF 467
                        .||.|             :|:.|::..: |.                |.:|||
Human   592 KKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVF 656

  Fly   468 LTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAET 532
            |.|.:.|.|.|:.| :.....||  ....::|:::.:|.:.|.|:|:|.|....||||:||||||
Human   657 LPGWNLIYTMQKHL-EMNPHFGS--HRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAET 718

  Fly   533 SLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYK 597
            |:||::::||||....|...|.:...|.:...|..||.:..||.|||||..||.||.|.:...::
Human   719 SITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFE 783

  Fly   598 HELEDNTVPEIQRINLGNAVLMLKALGINDLIHF--DFLDPPPHETLVLALEQLYALGALNHHGE 660
             .||.:..||:.|..|....|.:|.|.:..:..|  ..::|||.:.::.|...|..|.||:.:.|
Human   784 -RLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDE 847

  Fly   661 LTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRP------KDKIIHADT 719
            ||.|||.:|:.|::|..|||::....:...:.:.||||     :..|..|      :...||.:.
Human   848 LTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAA-----ATCFPEPFINEGKRLGYIHRNF 907

  Fly   720 ARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVS 784
            |...|:    ||::||.|:..|.:.....:.....|.:::.:..| .:|......:|..||.:.|
Human   908 AGNRFS----DHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMA-TLRMTWEAKVQLKEILINS 967

  Fly   785 CLPE 788
            ..||
Human   968 GFPE 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)37CbNP_609946.1 HrpA 222..867 CDD:224557 195/631 (31%)
DEXDc 269..408 CDD:238005 57/143 (40%)
HELICc 491..581 CDD:197757 35/89 (39%)
HA2 651..735 CDD:214852 27/89 (30%)
OB_NTP_bind 770..869 CDD:285018 6/19 (32%)
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250 21/135 (16%)
DSRM 5..69 CDD:214634
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118
DSRM 181..251 CDD:214634 9/70 (13%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186 1/3 (33%)
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325 21/104 (20%)
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236 0/1 (0%)
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 121/450 (27%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 200/685 (29%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 10/66 (15%)
HrpA 381..1095 CDD:224557 193/619 (31%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 139/417 (33%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 3/19 (16%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 29/96 (30%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 6/14 (43%)
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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