Protein Alignment l(2)37Cb and DQX1

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_598376.2
• Gene: DQX1 / 165545
• HGNCID: 20410
• Length: 717
• Species: Homo sapiens
• Alignment Length: 685
• Identity: 228/685 - (33%)
• Similarity: 365/685 - (53%)
• Gaps: 58/685 - (8%)

  Fly   229 SSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQ--VLIIEGETGSGKTTQVPQYLVE 291
            |||..||.::          |::||::..:...:..::.:.  |:::.||.||||:||:||:..|
Human    32 SSRYYELLKQ----------RQALPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAE 86

  Fly   292 ----AGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDG 352
                .||.|.:  :..|||..:||.|:|.|||:||.:.||:||||||..||||...|:|::..|.
Human    87 FALARGFQKGQ--VTVTQPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDR 149

  Fly   353 TLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKD--IARFRPELKLLISSATLDAEKFSA 415
            .|.:|..|.....::.|:::|||.||::.:|.|.||::|  :.:...:|::::.:......|..|
Human   150 LLLQEVASTRGTGAWGVLVLDEAQERSVASDSLQGLLQDARLEKLPGDLRVVVVTDPALEPKLRA 214

  Fly   416 FFDDAPIFRI---PGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETC 477
            |:.:.||..|   ||.| |..|::...| .|.::|.|.:||::...:..||:||||..::||..|
Human   215 FWGNPPIVHIPREPGER-PSPIYWDTIP-PDRVEAACQAVLELCRKELPGDVLVFLPSEEEISLC 277

  Fly   478 QEVLHDRVKRL---GSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNI 539
            .|.|...|:.|   |...|   |:|::.:....:|| ::|..  :||||::...:|:.|.::.:|
Human   278 CESLSREVESLLLQGLPPR---VLPLHPDCGRAVQA-VYEDM--DARKVVVTHWLADFSFSLPSI 336

  Fly   540 IYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNT 604
            .:|||.|...::.:|.|...|..::.||||..|..|..||....||.|..||.....:.|.....
Human   337 QHVIDSGLELRSVYNPRIRAEFQVLRPISKCQAEARRLRARGFPPGSCLCLYPKSFLELEAPPLP 401

  Fly   605 VPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMA 669
            .|.:...||.:.||:||...|.:.....|||.|..|.|:.|||.|..|.||:..|:|:.||..::
Human   402 QPRVCEENLSSLVLLLKRRQIAEPGECHFLDQPAPEALMQALEDLDYLAALDDDGDLSDLGVILS 466

  Fly   670 EFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTA--RKNFNHMHGDHL 732
            |||:.|.:.|.||||.::.|.:||:|:||||:.... |.||.   :.|:.|  |:...|..|||.
Human   467 EFPLAPELAKALLASCEFDCVDEMLTLAAMLTAAPG-FTRPP---LSAEEAALRRALEHTDGDHS 527

  Fly   733 SLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLP------ETVN 791
            ||:|||..:.::.....||....:.:.::.:|..:|.:|:.||||:|:.:  .||      ...:
Human   528 SLIQVYEAFIQSGADEAWCQARGLNWAALCQAHKLRGELLELMQRIELPL--SLPAFGSEQNRRD 590

  Fly   792 VRKAATAGYFYHVARLSKG-GHYKTIKHNQTVMI-----HPNSSLFEELPRWVLYHELVFTSKEY 850
            ::||..:|||..|||.:.| |:|..:.|.....:     :.:.......|.|||||....:....
Human   591 LQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSSYCCYRSRRAPARPPPWVLYHNFTISKDNC 655

  Fly   851 MRQVIEIESKWLLEVAPHYYKA----KELEDSTNK 881
            :..|.||:.:.|:|:||.|:.:    .|..|..|:
Human   656 LSIVSEIQPQMLVELAPPYFLSNLPPSESRDLLNQ 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	8/37 (22%)
		HrpA	251..>868	CDD:441249	217/644 (34%)
DQX1	NP_598376.2	HrpA	44..>615	CDD:441249	204/586 (35%)
		DEXQc_DQX1	45..224	CDD:350744	64/180 (36%)
		DEAQ box. /evidence=ECO:0000305|PubMed:11353393	170..173		2/2 (100%)
		OB_NTP_bind	591..674	CDD:400182	25/82 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..717