Protein Alignment l(2)37Cb and Dhx57

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001157231.1
• Gene: Dhx57 / 106794
• MGIID: 2147067
• Length: 1388
• Species: Mus musculus
• Alignment Length: 1155
• Identity: 294/1155 - (25%)
• Similarity: 468/1155 - (40%)
• Gaps: 336/1155 - (29%)

  Fly     4 KNRKRTASSSSSGEEPDSEEESRLKDL-QERDEFASRL-KKRDDDRTRNVVDSTGGRRAIEEATK 66
            :..:..|..|..||:.....::|:..: .|.|...::. |.:..:.::||.|::      .|..|
Mouse   248 RQEETLALKSICGEKFIERIQNRVWTIGLELDYLTNKFCKSKQKESSKNVRDTS------PETCK 306

  Fly    67 -----------RLKLEHE----------DRDKIVPHLRLQSRRQYLEK-----RKDDK------- 98
                       :.|.:||          :|:...|||.......::.:     .||.|
Mouse   307 FYLKGNCKFGSKCKFKHEVPPHQMIGRAERNVNDPHLDADDDTTFMYELQIRFSKDHKYPYQAPL 371

  Fly    99 VA--------ELEADILDDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQ-RYNMP 154
            ||        .|...:...|:|:.:::...:..|...|....| :.:|.|..:.|...| :|::|
Mouse   372 VAFYSTNENLPLACRLHISEFLYGKALEFAKTSEPVVYSLITL-LEEESEIVKLLTHTQHKYSVP 435

  Fly   155 ------------------------------QDLKKGERSEYVEVD------------EFEKQPNS 177
                                          ..:.:|||...:|.|            |.|...|.
Mouse   436 PVNVPPVPSETRISKPAYRKPVVPSNTFLSNQMLEGERLSELEEDADEDEGPASIIVENESYVNL 500

  Fly   178 EQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKR 242
            :::.::       |:...||...||                       .....||.::.:..|:.
Mouse   501 KKRSYK-------RYDRPAKSLFAE-----------------------NSKICRQFQMKQASRQF 535

  Fly   243 LTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIG---CT 304
            ..:.:.|:.||.:..:|.::..:.:|||::|.|.||.|||||:||::::.......:.:.   ||
Mouse   536 HAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICT 600

  Fly   305 QPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSV 369
            ||||::|:|||.|||:|...::|..|||.||.|...|..|.|.|.|.|.|.|....:..|...:.
Mouse   601 QPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTH 665

  Fly   370 MIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDI 434
            :|:||.||||..:|.|..::|||...|..|::::.||||||..||.:|...|:..||||.:|||.
Mouse   666 IIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQ 730

  Fly   435 FYTKAPEADYIDACCV-------------SVLQI------------------------------- 455
            |:.:       ||..|             |:.||
Mouse   731 FFLE-------DALAVTRYVLQDGSPYMRSMKQIAKEKLKARHNRTAQEEVEEDLRLSLHLQDEE 788

  Fly   456 --------------------------------------------------------HATQPLGDI 464
                                                                    ||..| |.:
Mouse   789 ESVKDTIPDQQLDFKQLLIRYKGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHAYPP-GAV 852

  Fly   465 LVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNI 529
            ||||.|..||:...|.|.........:....::.|::::|.|:.|..:|...|....|:|::|||
Mouse   853 LVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNI 917

  Fly   530 AETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAW 594
            ||||:|||:::||||.|..|:..:::..|||||....:|:|:|.||.|||||.|.|.||.|:|:.
Mouse   918 AETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSH 982

  Fly   595 AYKHELEDNTVPEIQRINLGNAVLMLKALGI----NDLIHFDFLDPPPH-ETLVLALEQLYALGA 654
            .|.|:|....:|||||:.|....|.:|.|.:    |....|..|..||| ::|..:..:|..|||
Mouse   983 HYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGA 1047

  Fly   655 LNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADT 719
            |....:||.||..:|..|||..:||::|....::|.:..:||||.|:..|. |..|.||...|:.
Mouse  1048 LTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSP-FVSPWDKKEEANQ 1111

  Fly   720 ARKNFNHMHGDHLSLLQVYNQW-------AETDYSTQWCYENFIQYRSMKRARDVREQLVGLM-- 775
            .:..|...:.|:|:||..|..|       |...|:  :|.:||:..|:::....::.|...|:
Mouse  1112 KKLEFAFANSDYLALLCAYKGWQLSTKESARASYN--YCRQNFLSGRTLQEMASLKRQFTELLSD 1174

  Fly   776 ----------QRVE--------------------------IDMVSC---LPETVNVR------KA 795
                      :.:|                          |..|.|   .|..|.|:      :.
Mouse  1175 IGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQK 1239

  Fly   796 ATAGYFYHVARLS-KGGHYKTI-KHNQTVMIHPNSSLFE----ELPRWVLYHELVFTSKEYMRQ- 853
            .::|    |.||. |....|.: |::..|.|||:|..::    :.| ::||||.:.||:.::|.
Mouse  1240 TSSG----VVRLQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSP-YLLYHEKIKTSRVFIRDC 1299

  Fly   854 -------------------------VIEIESKWLLEVAPHYYKA---KEL 875
                                     |:.::..|:..||..:..|   |||
Mouse  1300 SMVSVYPLVLFGGGQVNVQLQRGAFVVSLDDGWIRFVAASHQVAELVKEL 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	57/346 (16%)
		HrpA	251..>868	CDD:441249	236/810 (29%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD_DHX57	243..425	CDD:467661	33/183 (18%)
		zf_CCCH_4	305..323	CDD:465719	2/17 (12%)
		HrpA	545..>1172	CDD:441249	204/637 (32%)
		DEVH box	669..672		2/2 (100%)
		OB_NTP_bind	1215..1312	CDD:400182	26/101 (26%)