Protein Alignment l(2)37Cb and dhx37

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_068078944.1
• Gene: dhx37 / 100009635
• ZFINID: ZDB-GENE-030131-4505
• Length: 1179
• Species: Danio rerio
• Alignment Length: 1061
• Identity: 318/1061 - (29%)
• Similarity: 480/1061 - (45%)
• Gaps: 212/1061 - (19%)

  Fly     4 KNRKRTASSSSSGEEPDSEEESRLKD---LQERDEF------ASRLKKRDDDRTRNVVDSTGGRR 59
            |.|:::.|..::..:..:..:..::|   |:..|:.      |::.||:..:|     ..|..:.
Zfish    37 KGRQQSTSVQTAAADRQTNVQVEIQDGAVLKGVDDCNALVLPATKTKKQKVER-----PVTKKKA 96

  Fly    60 AIEEATKRLKLEHEDRDKIVPHLRLQSRRQYLEKRKDDKVAELEADIL---------DDEYLFDE 115
            ..::..|.|:...|.:||      ...|.:.|.|..:.::.|.|..:|         ...|...|
Zfish    97 LTKKQRKNLEKVLEQKDK------KAHRAEVLSKLAEVQLPEAELKLLYTTAKLGTGGKLYHIKE 155

  Fly   116 SVLTKREKEEREYKKQLLNIA--KEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSE 178
            ||...::......|...|:.|  |...:|.|.|......|.:..:..:.||..:..|.||:..||
Zfish   156 SVNEGQDGGSSSVKISSLSGANRKRRREADEEEEENESEMSESSEDDDDSEESDSSEEEKEKISE 220

  Fly   179 QKKWEAEQLASA-RFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKR 242
            :|..|.:|.... :.....|:|..:||.:.....:.|...|:.:      ...|.||
Zfish   221 EKHTEEQQQQQVLKEETKPKEADMKEEKKAETWTKEDCKPAVFI------PVERLPE-------- 271

  Fly   243 LTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPR 307
              :.|.|..|||...::.::.|||:|:.:::.|||||||||||||:|.||||.....:||.|:||
Zfish   272 --IQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGIIGVTEPR 334

  Fly   308 RVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMII 372
            ||||:|::.|||.||.:..| .|.|.||:|...::.|.:|.||||.|.:|...:..|..|||:||
Zfish   335 RVAAISMSHRVATEMNLSSG-VVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSVIII 398

  Fly   373 DEAHERTLHTDILFGLVKDIARFRPE----LKLLISSATLDAEKFS----AFFDDAPIFRIPGRR 429
            ||||||:::||||.||:..|...|.:    :||:|.||||..|.|:    .|....|:.::..|:
Zfish   399 DEAHERSVYTDILIGLLSRIVPLRNKKGLPMKLIIMSATLRVEDFTENKRLFSSPPPVIKVEARQ 463

  Fly   430 YPVDIFYTK-APEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIET-CQ-------------- 478
            :.|.:.:.| .|..||.......:.:||...|.|.||||||||.|:.: |:
Zfish   464 FAVTVHFNKRTPMDDYTGETFRKICKIHRMLPPGGILVFLTGQAEVHSVCRRLRKAFPYKPNREH 528

  Fly   479 ----EVLHD-----RVKRL-------------------GSKIRE--------------------- 494
                |...|     |.|:.                   |.:.|:
Zfish   529 TDMMETEEDLKKSKRAKKKNVSLPRINLDNYSALPVDEGDEDRQAGIDEDDGEGSDLELELGDHP 593

  Fly   495 -------------LIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPG 546
                         |.|:|:|:.|..:.|||:|.|.|..:|..::|||:|||||||..|.||:|.|
Zfish   594 DTDHEEKADPSIPLYVLPLYSLLAPEQQAKVFRPPPAGSRLCVVATNVAETSLTIPGIKYVVDCG 658

  Fly   547 FAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRI 611
            ..|:..::..||:.|..|..||:|||||||||||||.||.|:|||:: |...:....:..||.|.
Zfish   659 RVKKRFYDRVTGVSSFKVTWISQASANQRAGRAGRTEPGHCYRLYSS-AVFGDFSLFSEAEITRR 722

  Fly   612 NLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALN---HHGELTK---------- 663
            .:.:.||.:|.|.|..:::|.|..||..|.|:.|.|.|.:||||.   .||.|::
Zfish   723 PVEDLVLQMKDLNIEKVVNFPFPTPPSSEALIAAEELLISLGALEKPARHGRLSEMEKARLSCPI 787

  Fly   664 --LGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAI--FYRPKDKIIHADTARKNF 724
              |||.||.|||.|...|||....:..|.:.::||.:.::|....  :.||      |.:..:|.
Zfish   788 SPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVREIFEDYDRP------AGSEEENV 846

  Fly   725 NHMHGDHLSLLQVYNQWAETDYS----------------------TQWCYENFIQYRSMKRARDV 767
            . |.|.....:|:...||....|                      .|:|.||.:::::|...|.:
Zfish   847 K-MSGKKARSVQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLTPQFCEENGLRFKAMLEIRRL 910

  Fly   768 REQLVGLMQRVEID---------------MVSCLPETVNVRKAATAGYFYHVARLSKG------- 810
            |.||...:..|..|               .|.||      |:...||...|:||..:.
Zfish   911 RGQLTNAVNAVCADADVYVDNKMAPPTEAQVLCL------RQIVLAGLGDHIARRVQAEELLDPK 969

  Fly   811 --GHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAK 873
              ..|||...:..|.|||:|:|.:.||.:|:|.|::.|:|.|||.|..::..|:.::.|.|....
Zfish   970 WRNAYKTPLLDDPVFIHPSSALHKTLPEFVVYQEIMETTKMYMRGVCAVQDDWIPKLLPQYCHFS 1034

  Fly   874 ELEDSTNKKMPKVAGRAEMAQ 894
            ..|:|...:...:.||.:..|
Zfish  1035 APEESPAPRFCPLIGRVKCHQ 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	59/281 (21%)
		HrpA	251..>868	CDD:441249	256/765 (33%)
dhx37	XP_068078944.1	HrpA	279..>832	CDD:441249	205/554 (37%)
		OB_NTP_bind	944..1030	CDD:400182	29/91 (32%)