DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and TYRDC

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001329473.1	Gene:	TYRDC / 828986	AraportID:	AT4G28680	Length:	566	Species:	Arabidopsis thaliana

Alignment Length:	538	Identity:	215/538 - (39%)
Similarity:	313/538 - (58%)	Gaps:	61/538 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DGNGKAN-ISPDKLDPKVSIDMEAPEFKDFAKTMVDFIAEYLENIRER----RVLPEVKPGYLKP 75
            :|||||| ....|:.|     |::...::....||||||:|.:|:::.    .||.:|:||||:.
plant    35 NGNGKANGAKVVKMKP-----MDSELLREQGHIMVDFIADYYKNLQDSPQDFPVLSQVQPGYLRD 94

  Fly    76 LIPDAAPEKPEKWQDVMQDIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTW 140
            ::||:|||:||..::::.|:.:.||||:|||.||.:.||:.::.|....:.:||:..::.:||||
plant    95 MLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTW 159

  Fly   141 IASPACTELEVVMMDWLGKMLELPAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKEL 205
            :.|||.||||::::|||.|:|:||..||:...|.||||||||..|:.||.:|.|:.:.||:|.:
plant   160 LTSPAATELEIIVLDWLAKLLQLPDHFLSTGKGNGGGVIQGTGCEAVLVVVLAARDRILKKVGK- 223

  Fly   206 HPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVK------LRSVQSENHRMRGAALEKAIEQDV 264
                   |:|.:||.|.|||.|||..:|.|:||:.      |::..|.|:.|...:||:||..|:
plant   224 -------TLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDL 281

  Fly   265 AEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESAD 329
            |:|.|||:...|:|||:|.|.|.|...|.:..|:.:|:||||||||:|.||||||..:.|||:||
plant   282 AKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENAD 346

  Fly   330 SFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYL--KHDMQGSAPDYRHWQIPLGRRF--- 389
            |||.|.|||:..|..||.:|:||...:::|...:|.||  |...:.:..:|:.|||.|.|||
plant   347 SFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRFF 411

  Fly   390 -------------------------RALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSR 429
                                     |:||||.||||||.|||:..||.|.|.||.|.|....|..
plant   412 ISPFDVVFAGPISLTNLYVHAFDLYRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPS 476

  Fly   430 FELAAEINMGLVCFRL-------KGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFT 487
            ||:.......||||||       ...||||..||..:|..|.|.:....:...:.||.|:.:..|
plant   477 FEVVTTRYFSLVCFRLAPVDGDEDQCNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLT 541

  Fly   488 QSEDMEYSWKEVSAAADE 505
            :.:.:..:|:.:...|.:
plant   542 EEKHVTEAWQIIQKHASK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	180/418 (43%)
TYRDC	NP_001329473.1	PLN02590	2..566	CDD:178200	215/538 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG57772
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	O	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830