DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and hdc

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_005169965.1	Gene:	hdc / 793609	ZFINID:	ZDB-GENE-080102-5	Length:	608	Species:	Danio rerio

Alignment Length:	477	Identity:	232/477 - (48%)
Similarity:	324/477 - (67%)	Gaps:	5/477 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100
            |:..|:....|.||::|.:||..||||||:|:|:||:::||:|.:||.:||.|..:|||:|.:||
Zfish     1 MQPQEYMLRGKEMVEYIHQYLTGIRERRVVPDVQPGFMRPLLPSSAPYEPEDWSTIMQDVENIIM 65

  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165
            |||.||.||..|||||..||:|:::.|||:.||.|:||||.:||||||||:.::|||.|.|.||.
Zfish    66 PGVVHWQSPHMHAYFPALNSWPSLLGDMLADAINCLGFTWASSPACTELEMCVLDWLCKALGLPD 130

  Fly   166 EFL-ACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKE--LHPEWDEHTILGKLVGYCSDQAH 227
            .:| ......|||::|.|.||.||||||.|:..::.::|.  .|.:.||..:..:||.|.|||||
Zfish   131 HYLHHHPQSTGGGILQSTVSECTLVALLAARKDRILQMKSEATHTDTDESVLNSRLVAYASDQAH 195

  Fly   228 SSVERAGLLGGVKLRSVQSEN-HRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDEC 291
            ||||:|||:..||:|.:|::. ..:||..|::|:|:|...||||.....|||:|..|:||.|||.
Zfish   196 SSVEKAGLISLVKIRFLQTDAVFSLRGETLQRAVEEDRRSGLIPVMVCATLGSTGVCSFDRLDEL 260

  Fly   292 GPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWV 356
            |||..:..||:||||||||||.:|||.|:.:.||:.||||.|||.|||||:|||:|.|:|:...:
Zfish   261 GPVCVREGLWLHVDAAYAGSALLCPELRYFLDGIQFADSFVFNPSKWMLVHFDCTAFWVKNKMKL 325

  Fly   357 VNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFG 421
            ...|.||||||:|| ..:|.|:.||||||.||||:||||||:|.:|::.||.|||.....||.|.
Zfish   326 QQTFTVDPLYLRHD-NSNATDFMHWQIPLSRRFRSLKLWFVIRSFGLKKLQEHIRHGVEMAKLFE 389

  Fly   422 DLCVADSRFELAAEINMGLVCFRLKGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRF 486
            .|...|:.|::.|:.::|||.|.|:..|...:.||:::...|.:.|:||.:.:...||.::.|:.
Zfish   390 SLVRNDTHFQIPAQRHLGLVVFCLRAGNAATQELLRKLTRSGRMFLIPAAVGNQLILRFSVTSQL 454

  Fly   487 TQSEDMEYSWKEVSAAADEMEQ 508
            |..:|:...|..:..||.|:.|
Zfish   455 TTEQDIRRDWSLIQQAAREVLQ 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	198/379 (52%)
hdc	XP_005169965.1	Pyridoxal_deC	35..414	CDD:278699	198/379 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730