DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ddc and Gadl1

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001382689.1	Gene:	Gadl1 / 73748	MGIID:	1920998	Length:	522	Species:	Mus musculus

Alignment Length:	533	Identity:	140/533 - (26%)
Similarity:	223/533 - (41%)	Gaps:	70/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NGKANISPDKLDPKVSID---MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEV----------K 69
            :|:..::|.|..| :.:|   :..|:..  .|....|:.|....|.|..||...          .
Mouse    16 SGQKEMTPGKKIP-IFVDGVVLNGPQTD--VKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWQP 77

  Fly    70 PGYLKPLIPDAAPEKPEKWQDVMQDIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIA 134
            |..|:.|:.....:..|....:::..:.||...|...| |:|.........|.::.|.:::.|:.
Mouse    78 PEQLRQLLDLEMRDTGESQDKLLKLCQDVIHFSVKTNH-PRFFNQLYAGLDYYSLAARIITEALN 141

  Fly   135 CIGFTWIASPACTELEVVMMDWLGKMLELPAEFLACSGGK-GGGVIQGTASESTLVALLGAKAKK 198
            ...:|:..||....:|..:   |.||:|       |.|.| |.|:.....|.|.:.|:..|:.:.
Mouse   142 PSIYTYEVSPVFLLVEEAV---LKKMIE-------CVGWKEGDGIFNPGGSVSNMCAMNLARYRH 196

  Fly   199 LKEVKELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKLRSVQSENHRMRGAA----LEKA 259
            ..::||     ...:.|.:|:.:.|.:.|.|:::|....|:..::|.......||..    |||.
Mouse   197 CPDIKE-----KGLSGLPRLILFTSAECHYSMKKAASFLGIGTQNVYFVETDGRGKMIPEDLEKQ 256

  Fly   260 IEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKG 324
            |.|...||.:||....|.|||...|||.|||...|..:|.||:||||::.|||.:..::|.|:.|
Mouse   257 IWQARQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHG 321

  Fly   325 IESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVN---------AFNVDPLYLKHDMQGSAPDYRH 380
            |..|||..:||||.::....|||:.:||.|.::.         .|..|..|   |:.....|.
Mouse   322 IHRADSVAWNPHKMLMAGIQCSALLVKDKSDLLKKCYSAKATYLFQQDKFY---DVSYDTGDK-- 381

  Fly   381 WQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCF-- 443
             .|...||..|.|.|...:..|...|:..:.|....::...|.......|:|..|.....|||
Mouse   382 -SIQCSRRPDAFKFWMTWKALGTSGLEERVNRAFALSRYLVDEIKKREGFKLLMEPEYTNVCFWY 445

  Fly   444 ---RLKGSNERNE----------ALLKRINGRGHIHL--VPAKIKDVYFLRMAICSRFTQSEDME 493
               .|:...|..|          |:.:::..:|.:.|  .|.:.| |.|.|..:.|.....|||:
Mouse   446 IPPSLREMEEGPEFWRKLSLVAPAIKEKMMKKGSLMLGYQPHRGK-VNFFRQVVISPQVSREDMD 509

  Fly   494 YSWKEVSAAADEM 506
            :...|:.:...:|
Mouse   510 FLLDEIDSLGRDM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	110/394 (28%)
Gadl1	NP_001382689.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810