DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ddc and gad2

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001017708.2	Gene:	gad2 / 550403	ZFINID:	ZDB-GENE-030909-9	Length:	583	Species:	Danio rerio

Alignment Length:	519	Identity:	131/519 - (25%)
Similarity:	210/519 - (40%)	Gaps:	83/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PEFKDFAKTM------VDFIAEYL-ENI-RERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDI 95
            |.....||||      ||.:..|: |:. |..:|:....|..|.........::||...|::...
Zfish    97 PALDGDAKTMNFLQEVVDILLAYIVESFDRSTKVIDFHYPNELLQRNNWELSDEPETLDDILISC 161

  Fly    96 ERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKM 160
            ...:...:...| |::.....|......:.||.|:.......||:..:|....||.|.   |.||
Zfish   162 RATLKYAIKTAH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEVAPVFVLLEYVT---LKKM 222

  Fly   161 LELPAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQ 225
            .|:    :....|.|.|:.....:.|.:.|:|.|:.|...||||     ...:.:.:||.:.|:.
Zfish   223 REI----IGWQDGHGDGIFSPGGAISNMYAMLLARYKMFPEVKE-----KGMSSVPRLVAFTSEH 278

  Fly   226 AHSSVERAGLLGGVKLRSV----QSENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFD 286
            :|.|:::.....|:...||    ..|..:|..:.||:.|.:...:|.:||:...|.|||...|||
Zfish   279 SHFSIKKGAAALGIGTESVICIKADERGKMIPSDLERRIIEAKQKGYVPFFVSATAGTTVYGAFD 343

  Fly   287 YLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLK 351
            .|.....:..||::|:|||.|:.||..:..::|..:.|:|.|:|..:||||.|.|...|||:.::
Zfish   344 PLIAIADICKKHDVWMHVDGAWGGSLLMSRKHRWKLNGVERANSMTWNPHKMMAVPLQCSALLVR 408

  Fly   352 DPSWVVNAFNVDPLYL----KH-DMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIR 411
            :...:.:...:...||    || |:|....|.   .:..||.....|||.:.|..|....:|.|.
Zfish   409 EEGLMQSCNQMQACYLFQQDKHYDLQYDTGDK---ALQCGRHVDIFKLWLMWRAKGTIGFEAQID 470

  Fly   412 RHCNFAKQF--------GDLCVADSRFELAAEINMGLVCF--------RLKGSNERNEALLKRIN 460
            :....::..        |...|.|.:   ....|   |||        .|:...||    :||
Zfish   471 KCLELSEYLYNKIKDREGYQMVFDGK---PQHTN---VCFWYLPPGVRYLEDKVER----MKR-- 523

  Fly   461 GRGHIHLVPAKIK------------------DVYFLRMAICSRFTQSEDMEYSWKEVSAAADEM 506
                :|.|...||                  .|.|.||.|.:.....||:::..:|:.....::
Zfish   524 ----LHKVAPVIKARMMEYGTTMVSYQPQGDKVNFFRMVISNPAATFEDIDFLIEEIERLGQDL 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	103/400 (26%)
gad2	NP_001017708.2	Pyridoxal_deC	136..506	CDD:278699	103/391 (26%)
gad2	NP_001017708.2	TIM_phosphate_binding	511..>561	CDD:304361	14/59 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810