DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and ddc

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_998507.1	Gene:	ddc / 406651	ZFINID:	ZDB-GENE-040426-2656	Length:	480	Species:	Danio rerio

Alignment Length:	477	Identity:	284/477 - (59%)
Similarity:	375/477 - (78%)	Gaps:	3/477 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100
            |:|.||:...:.|||::|:|:|||.:|:|.|:|:||||:.|||:.|||:||.::||::|||||||
Zfish     1 MDAAEFRRRGREMVDYVADYIENIEKRQVYPDVEPGYLRSLIPEEAPEEPESYEDVVKDIERVIM 65

  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165
            |||||||||.|:||||||:||||::||:|.|||.||||:|.|||||||||.||:|||||||:||.
Zfish    66 PGVTHWHSPYFYAYFPTAHSYPAMLADILCGAIGCIGFSWAASPACTELETVMLDWLGKMLKLPE 130

  Fly   166 EFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSV 230
            :|||.:.||||||||.||||:||:.||.|::|.::.::..||:..|..|:.|||.|.||||||||
Zfish   131 DFLAGTKGKGGGVIQSTASEATLITLLAARSKIVRLIQADHPDRSETDIISKLVAYSSDQAHSSV 195

  Fly   231 ERAGLLGGVKLRSVQSEN-HRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPV 294
            |||||:|||:::.:.::: ..:||.|||:.:::|.|.|||||:...|||||.|||||.:.|.||:
Zfish   196 ERAGLIGGVRMKKIPTDSKFSVRGDALERILKEDKAAGLIPFFFCATLGTTASCAFDCITELGPI 260

  Fly   295 GNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNA 359
            .|...:|:|:|||||||||||||:|.|:.|||.|||||||||||:|:||||||||:|..:.::.|
Zfish   261 CNAEKMWMHIDAAYAGSAFICPEFRPLLNGIEFADSFNFNPHKWLLINFDCSAMWVKKRADIIGA 325

  Fly   360 FNVDPLYLKHDMQ--GSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGD 422
            |.::|||||||.|  |...||||||||||||||:||:|||.|:||::.|||:||:|...||:|..
Zfish   326 FKMEPLYLKHDHQESGLVTDYRHWQIPLGRRFRSLKMWFVFRMYGLKALQAYIRKHVGLAKEFEA 390

  Fly   423 LCVADSRFELAAEINMGLVCFRLKGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFT 487
            ...||.|||::|::.||||||||||.||.:|.||||||....|||||..:..::.||.|:|:|.|
Zfish   391 FVRADQRFEISADVVMGLVCFRLKGPNELSENLLKRINSARKIHLVPCHLAGLFVLRFAVCARAT 455

  Fly   488 QSEDMEYSWKEVSAAADEMEQE 509
            :|..::.:|..:...|.|:.||
Zfish   456 ESRHVQEAWCHIRQLASELLQE 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	239/378 (63%)
ddc	NP_998507.1	AAT_I	1..478	CDD:302748	284/477 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595381
Domainoid	1	1.000	519	1.000	Domainoid score	I292
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H618
Inparanoid	1	1.050	608	1.000	Inparanoid score	I888
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		oto41447
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	LDO	PTHR11999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3838
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800