DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and Gad1

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	124/513 - (24%)
Similarity:	207/513 - (40%)	Gaps:	78/513 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PEFKDFAKTMVDFIAEYLE--NIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIMP 101
            ||.::|...::|.:.::::  |.|..:||....|..:|.|:....|::....|.:::|....:..
  Fly    31 PETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTLKY 95

  Fly   102 GVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPAE 166
            .|...| |.|...........::..:.|:.......||:..:|....:|.|:   |.||.|:
  Fly    96 QVKTGH-PHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVV---LTKMREI--- 153

  Fly   167 FLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEH---TILGKLVGYCSDQAHS 228
             :..||  |..::....|.|.|.|.|.|:.|       :.|.:.||   .:.|.||.:.|||.|.
  Fly   154 -IGWSG--GDSILAPGGSISNLYAFLAARHK-------MFPNYKEHGSVGLPGTLVMFTSDQCHY 208

  Fly   229 SVERAGLLGGVKLRS---VQSENH-RMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLD 289
            |::....:.|:....   |.|:.| :|..:.||:.|.:..|:|.|||:...|.|||...|||.::
  Fly   209 SIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDIN 273

  Fly   290 ECGPVGNKHNLWIHVDAAYAGSAFICPEYRH-LMKGIESADSFNFNPHKWMLVNFDCSAMWLKDP 353
            ....:..|:|.|:|:|||:.|...:..::|| ...|:|.|||..:||||.|.....||.:..|:.
  Fly   274 TIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKED 338

  Fly   354 SWVV--NAFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNF 416
            ..::  |..:.:.|::.......:.|.....|..||.....|||...|..|.|..:....|....
  Fly   339 GLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMEL 403

  Fly   417 AK-QFGDLCVADSRFEL-------------------------AAEINMGLVCFRLKGSNERNEAL 455
            .: |...:.....||.|                         ..|:.:|.:|..:||...:...|
  Fly   404 VQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQKGTL 468

  Fly   456 L-------KRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAADEM 506
            :       :|.|                |.|..|.|......|:::...|:....|::
  Fly   469 MVGYQPDDRRPN----------------FFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	104/411 (25%)
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	101/386 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740