Protein Alignment Ddc and HDC

DIOPT Version :9

• Sequence 1: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 243/505 - (48%)
• Similarity: 327/505 - (64%)
• Gaps: 37/505 - (7%)

  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100
            ||..|:::..:.|||:|.:||..:|||||.|:|:||||:..:|::|||.|:.|..:..||||:||
Human     2 MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIM 66

  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165
            |||.||.||..|||:|...|:|:::.|||:.||.|:||||.:||||||||:.:||||.|||.||.
Human    67 PGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPE 131

  Fly   166 EFL-ACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSS 229
            .|| .....:||||:|.|.|||||:|||.|:..|:.|:|...|:.||..:..:||.|.|||||||
Human   132 HFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSS 196

  Fly   230 VERAGLLGGVKLRSVQ-SENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGP 293
            ||:|||:..||::.:. .:|..:||.||:||||:|...||:|.:...|||||..||||.|.|.||
Human   197 VEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGP 261

  Fly   294 VGNKHN-----------------------------------LWIHVDAAYAGSAFICPEYRHLMK 323
            :...|:                                   ||:|:||||||:||:|||:|..:|
Human   262 ISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPEFRGFLK 326

  Fly   324 GIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRR 388
            |||.||||.|||.|||:|:|||:..|:||...:...|:|:|:||:|...|.|.|:.||||||.||
Human   327 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRR 391

  Fly   389 FRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCFRLKGSNERNE 453
            ||::|||||:|.:||:|||||:|.....||.|..|...|..||:.|:.::|||.|||||.|...|
Human   392 FRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTE 456

  Fly   454 ALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAA 503
            .:||.|...|.:.|:||.|:|...:|..:.|:||..:|:...|..:..||
Human   457 NVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAA 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	205/412 (50%)
HDC	XP_016877583.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730