DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and GAD2

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000809.1	Gene:	GAD2 / 2572	HGNCID:	4093	Length:	585	Species:	Homo sapiens

Alignment Length:	509	Identity:	117/509 - (22%)
Similarity:	213/509 - (41%)	Gaps:	62/509 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DMEAPEFKDFAKTMVDFIAEYLENI--RERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIER 97
            |.|.|... |.:.:::.:.:|:...  |..:|:....|..|.........::|:..::::...:.
Human   102 DGERPTLA-FLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQT 165

  Fly    98 VIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLE 162
            .:...:...| |::.....|......:.||.|:.......||:..:|....||.|.   |.||.|
Human   166 TLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVT---LKKMRE 226

  Fly   163 LPAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAH 227
            :    :...||.|.|:.....:.|.:.|::.|:.|...||||     .....|.:|:.:.|:.:|
Human   227 I----IGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKE-----KGMAALPRLIAFTSEHSH 282

  Fly   228 SSVERAGLLGGVKLRSV----QSENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYL 288
            .|:::.....|:...||    ..|..:|..:.||:.|.:...:|.:||....|.|||...|||.|
Human   283 FSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPL 347

  Fly   289 DECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDP 353
            .....:..|:.:|:|||||:.|...:..:::..:.|:|.|:|..:||||.|.|...|||:.:::.
Human   348 LAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREE 412

  Fly   354 SWVVNAFNVDPLYL----KH-DMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRH 413
            ..:.|...:...||    || |:.....|.   .:..||.....|||.:.|..|....:||:.:.
Human   413 GLMQNCNQMHASYLFQQDKHYDLSYDTGDK---ALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKC 474

  Fly   414 CNFAKQFGDLCVADSRFELAAE-----INMGLVCF-------RLKGSNERNEALLKRINGRGHIH 466
            ...|:...::......:|:..:     .|   |||       |....||...:.|.::     ..
Human   475 LELAEYLYNIIKNREGYEMVFDGKPQHTN---VCFWYIPPSLRTLEDNEERMSRLSKV-----AP 531

  Fly   467 LVPAKIKD--------------VYFLRMAICSRFTQSEDMEYSWKEVSAAADEM 506
            ::.|::.:              |.|.||.|.:.....:|:::..:|:.....::
Human   532 VIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	99/396 (25%)
GAD2	NP_000809.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pyridoxal_deC	138..509	CDD:278699	98/389 (25%)
		Substrate binding	181..183		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810