DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and Ddc

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001257781.1	Gene:	Ddc / 24311	RGDID:	2494	Length:	480	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	283/474 - (59%)
Similarity:	371/474 - (78%)	Gaps:	3/474 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100
            |::.||:...|.|||:||:||:.|..|.|.|:|:||||:.|||..||::||.::|:::|||::||
  Rat     1 MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRALIPTTAPQEPETYEDIIRDIEKIIM 65

  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165
            |||||||||.|.||||||:||||::||||.|||.||||:|.|||||||||.|||||||||||||.
  Rat    66 PGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPE 130

  Fly   166 EFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSV 230
            .|||...|:|||||||:|||:||||||.|:.|.:::::...||..:..::.|||.|.||||||||
  Rat   131 AFLAGRAGEGGGVIQGSASEATLVALLAARTKMIRQLQAASPELTQAALMEKLVAYTSDQAHSSV 195

  Fly   231 ERAGLLGGVKLRSVQSE-NHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPV 294
            |||||:||||::::.|: |:.||.|||.:|:|:|.|.|||||:.|||||||:.|:||.|.|.||:
  Rat   196 ERAGLIGGVKIKAIPSDGNYSMRAAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLEVGPI 260

  Fly   295 GNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNA 359
            .|:..:|:|:|||||||||||||:|:|:.|:|.|||||||||||:||||||||||:|..:.:..|
  Rat   261 CNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTEA 325

  Fly   360 FNVDPLYLKHDMQ--GSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGD 422
            ||:||:||:|..|  |...||||||||||||||:||:|||.|:|||:.|||:||:|...:.:|..
  Rat   326 FNMDPVYLRHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKLSHEFES 390

  Fly   423 LCVADSRFELAAEINMGLVCFRLKGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFT 487
            |...|.|||:..|:.:|||||||||||:.||.||:|||....|||||.:::|.:.||.|:|||..
  Rat   391 LVRQDPRFEICTEVILGLVCFRLKGSNQLNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCSRTV 455

  Fly   488 QSEDMEYSWKEVSAAADEM 506
            :|..::.:|:.:...|..:
  Rat   456 ESAHVQLAWEHIRDLASSV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	240/378 (63%)
Ddc	NP_001257781.1	Pyridoxal_deC	35..414	CDD:278699	243/381 (64%)
Ddc	NP_001257781.1	2 X approximate tandem repeats	58..178		83/119 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353283
Domainoid	1	1.000	522	1.000	Domainoid score	I290
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H618
Inparanoid	1	1.050	609	1.000	Inparanoid score	I889
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		oto97423
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	LDO	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770