DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ddc and Sgpl1

DIOPT Version :9

Sequence 1:NP_724163.1 Gene:Ddc / 35190 FlyBaseID:FBgn0000422 Length:510 Species:Drosophila melanogaster
Sequence 2:NP_001303602.1 Gene:Sgpl1 / 20397 MGIID:1261415 Length:568 Species:Mus musculus


Alignment Length:479 Identity:96/479 - (20%)
Similarity:163/479 - (34%) Gaps:149/479 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ISPDKLD-----PKVSIDMEAPEFKDFAKTMVD---FIAEYLENIRERRVLPEVKPGYLKPLIPD 79
            :|..|.|     |.:.:|      ||:.||:..   ..||.||.::|...:             |
Mouse    92 VSKAKKDLVKNMPFLKVD------KDYVKTLPAQGMGTAEVLERLKEYSSM-------------D 137

  Fly    80 AAPEKPEKWQDVMQDIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASP 144
            .:      ||:....       |..:...||              :.::|..|..  .||| ::|
Mouse   138 GS------WQEGKAS-------GAVYNGEPK--------------LTELLVQAYG--EFTW-SNP 172

  Fly   145 ACTELEVVMMDWLGKMLELPAEF--LACSGGKGG----GVIQGTASESTLVALLG----AKAKKL 199
                   :..|....:.:|.||.  :.||...||    |.:....:||.|:|...    |..|.:
Mouse   173 -------LHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGI 230

  Fly   200 KEVKELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKL-RSVQSENHRMRGAALEKAIEQD 263
            |..:.:.||                .||::.::|....|:|: |....:|..:...|:::||.::
Mouse   231 KTPEIVAPE----------------SAHAAFDKAAHYFGMKIVRVALKKNMEVDVQAMKRAISRN 279

  Fly   264 VAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPE---------YR 319
            .|      ..|.:.........|.:.|...:..::.:.:||||...|...:..|         :.
Mouse   280 TA------MLVCSTPQFPHGVMDPVPEVAKLAVRYKIPLHVDACLGGFLIVFMEKAGYPLEKPFD 338

  Fly   320 HLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDP-----LYLKHDMQGSAPDYR 379
            ..:||:.|..:   :.||:.......|.:...:..:....|.|..     :|....:.||.|   
Mouse   339 FRVKGVTSISA---DTHKYGYAPKGSSVVMYSNEKYRTYQFFVGADWQGGVYASPSIAGSRP--- 397

  Fly   380 HWQIPLGRRFRALKLWFVLRLYGVEN--LQA--HIRRHCNFAKQ----------FGD-----LCV 425
                  |....|  .|..|..:| ||  ::|  .|.:...|.|.          |||     :.:
Mouse   398 ------GGIIAA--CWAALMHFG-ENGYVEATKQIIKTARFLKSELENIKNIFIFGDPQLSVIAL 453

  Fly   426 ADSRFELAAEINMGLVCFRLKGSN 449
            ..:.|::....||    ...||.|
Mouse   454 GSNDFDIYRLSNM----MSAKGWN 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdcNP_724163.1 Pyridoxal_deC 70..446 CDD:278699 79/419 (19%)
Sgpl1NP_001303602.1 DOPA_deC_like 146..507 CDD:99743 79/400 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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