Protein Alignment Ddc and tdc-1

DIOPT Version :10

• Sequence 1: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_495743.1
• Gene: tdc-1 / 174327
• WormBaseID: WBGene00006562
• Length: 705
• Species: Caenorhabditis elegans
• Alignment Length: 506
• Identity: 256/506 - (50%)
• Similarity: 357/506 - (70%)
• Gaps: 11/506 - (2%)

  Fly     7 SNTIPTKQTDGNGKANISPDKLDPKVSID----MEAPEFKDFAKTMVDFIAEYLENIRERRVLPE 67
            |.|||:     ....:::|...||:.:.:    |...||:.:.|..||:|.:|||||::|||:|.
 Worm    49 STTIPS-----TPNMDVTPTVEDPRQNDNNASGMTRDEFRQYGKETVDYIVDYLENIQKRRVVPA 108

  Fly    68 VKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGA 132
            ::|||||.|||..||..||.::.||:|.|::||||:|||..|:||||||..||:|:|:|||||.|
 Worm   109 IEPGYLKDLIPSEAPNTPESFESVMEDFEKLIMPGITHWQHPRFHAYFPAGNSFPSIIADMLSDA 173

  Fly   133 IACIGFTWIASPACTELEVVMMDWLGKMLELPAEFLACS-GGKGGGVIQGTASESTLVALLGAKA 196
            |.|:||:|.|.||.||||::|:||.|||:.||||||..: .||||||||.:|||...|.||.|:.
 Worm   174 IGCVGFSWAACPAMTELELIMLDWFGKMIGLPAEFLPLTENGKGGGVIQSSASECNFVTLLAARF 238

  Fly   197 KKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKLRSVQSEN-HRMRGAALEKAI 260
            :.:||:::..|..:|..:|.||:.|||.:||||||:|.::|.||||.::::: .|:||..|..||
 Worm   239 EVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSSVEKACMIGMVKLRILETDSKFRLRGDTLRNAI 303

  Fly   261 EQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGI 325
            ::|...|||||:...|||||:.|:||.|.|.||:..::.||:||||||:||||||||:|.||.||
 Worm   304 QEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGPICKENELWLHVDAAYSGSAFICPEFRPLMNGI 368

  Fly   326 ESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFR 390
            |.|.|||.||:||:|:|||||.||::|...:..|..||||||:|.....:.|||||.|||.||||
 Worm   369 EYAMSFNTNPNKWLLINFDCSTMWVRDRFKLTQALVVDPLYLQHSWMDKSIDYRHWGIPLSRRFR 433

  Fly   391 ALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCFRLKGSNERNEAL 455
            :||||||:|:||::.||.:||.|...||:...|..||::||:..|:.|||||||:||.:|.|:.|
 Worm   434 SLKLWFVIRMYGIDGLQKYIREHVRLAKKMETLLRADAKFEIVNEVIMGLVCFRMKGDDELNQTL 498

  Fly   456 LKRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAADEM 506
            |.|:|..|.||:|||.:.|.:.:|..:|:.....:|:|.:::.::.|...:
 Worm   499 LTRLNASGRIHMVPASLGDRFVIRFCVCAENATDKDIEVAYEIIAQATQHV 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:395219	213/377 (56%)
tdc-1	NP_495743.1	Pyridoxal_deC	111..489	CDD:395219	213/377 (56%)