DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddc and Gad1

DIOPT Version :9

Sequence 1:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_032103.2	Gene:	Gad1 / 14415	MGIID:	95632	Length:	593	Species:	Mus musculus

Alignment Length:	514	Identity:	126/514 - (24%)
Similarity:	198/514 - (38%)	Gaps:	86/514 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 FAKTMVDFIAEYLENIRERRV----------LPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERV 98
            |...:||.:..|:....:|..          |.|...|:...|     .:.||..:.::.|....
Mouse   115 FLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLEL-----SDHPESLEQILVDCRDT 174

  Fly    99 IMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLEL 163
            :..||...| |:|.....|......:..:.|:.......||:..:|....:|.:.   |.||.|:
Mouse   175 LKYGVRTGH-PRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQIT---LKKMREI 235

  Fly   164 PAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHS 228
                :..|...|.|:.....:.|.:.:::.|:.|...|||.     .....:.|||.:.|:.:|.
Mouse   236 ----VGWSNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKT-----KGMAAVPKLVLFTSEHSHY 291

  Fly   229 SVERAGLLGGVKLRSV----QSENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLD 289
            |:::||...|....:|    .:|..::..|.||..|.....:|.:|.|...|.|||...|||.:.
Mouse   292 SIKKAGAALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKGYVPLYVNATAGTTVYGAFDPIQ 356

  Fly   290 ECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPS 354
            |...:..|:|||:|||||:.|...:..::||.:.|||.|:|..:||||.|.|...|||:.:|:..
Mouse   357 EIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLLQCSAILVKEKG 421

  Fly   355 WVVNA--------FNVDPLY-LKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHI 410
            .:...        |..|..| :.:|....|       |..||.....|.|.:.:..|....:..|
Mouse   422 ILQGCNQMCAGYLFQPDKQYDVSYDTGDKA-------IQCGRHVDIFKFWLMWKAKGTVGFENQI 479

  Fly   411 RRHCNFAKQFGDLCVADSRFELA--AEINMGLVCF-----RLKG---SNERNEALLKRINGRGHI 465
            .:....|............||:.  .|.....|||     .|:|   |.||.|.|
Mouse   480 NKCLELADYLYAKIKNREEFEMVFDGEPEHTNVCFWYIPQSLRGVPDSPERREKL---------- 534

  Fly   466 HLVPAKIKDVY------------------FLRMAICSRFTQSEDMEYSWKEVSAAADEM 506
            |.|..|||.:.                  |.||.|.:......|:::..:|:.....::
Mouse   535 HRVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	101/395 (26%)
Gad1	NP_032103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:365998	103/398 (26%)
		Substrate binding. /evidence=ECO:0000250	189..191		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810