Protein Alignment CG10561 and KDM1B

DIOPT Version :10

• Sequence 1: NP_476608.1
• Gene: CG10561 / 35189
• FlyBaseID: FBgn0002036
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001426046.1
• Gene: KDM1B / 221656
• HGNCID: 21577
• Length: 832
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 132/538 - (24%)
• Similarity: 209/538 - (38%)
• Gaps: 126/538 - (23%)

  Fly     8 SRRSLYNARVLQADNIGDKQRSPDLEAARQNTQIVVVGAGLAGLSAAQHLLSHGFRRTVILEATD 72
            :|:.|.|..||   ::|..|..  |.....|..::::|||.|||:||:.|.:.|.:.|| |||.|
Human   366 TRKGLINTGVL---SVGADQYL--LPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTV-LEAKD 424

  Fly    73 RYGGRI-NTQRFGDTYCELGAKWVKIDGSQDSMYELLRNTEGLGKQIKQPDRATYLQDGSRI-NP 135
            |.|||: :.:.|.......||:.|  :|..::...|:....|:... |..:|...:|:|.|| :|
Human   425 RIGGRVWDDKSFKGVTVGRGAQIV--NGCINNPVALMCEQLGISMH-KFGERCDLIQEGGRITDP 486

  Fly   136 AMVELIDTLFRQLCRGFKVSERVKTGGDLHSLDNVMNYFRTESDRIIGVSFQHPKDQLAAREIFQ 200
            .:.:.:|..|..|                  || |::.:|.:..::..|....     ...||::
Human   487 TIDKRMDFHFNAL------------------LD-VVSEWRKDKTQLQDVPLGE-----KIEEIYK 527

  Fly   201 SLFKE----FGSILGCCLEY--VNIEHITKCPVQQ----------------EQRPLYVPTGLDNV 243
            :..||    |..:.|..|::  .|:|:.....:.|                ....|..| |...:
Human   528 AFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTP-GYSVI 591

  Fly   244 VDDLIQNMDKAQLQTGKPVGQIQWTPAPMKSVGCLDGSLYNADHIICTLPLGVLKSFAGVLFRPT 308
            ::.|.:.:|   :|...|..|..........|...||:.|:|..::.|:||.:|:..| :.|.|.
Human   592 IEKLAEGLD---IQLKSPQVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGA-IQFNPP 652

  Fly   309 LPLDKMLAIRNLGFGNPLKIYLSYKKPIGRWLKGSLRPLGTLLNPSVEQQPERNWTQQV------ 367
            |...||.||.:||.|...||.|.:                          |.|.|..:|
Human   653 LSEKKMKAINSLGAGIIEKIALQF--------------------------PYRFWDSKVQGADFF 691

  Fly   368 --------------VEISQVPSSQH-VLEVHVGGGYYEEIEKLPDEELLEQITGLLRRCVSSHLV 417
                          |.....|..:| ||...:.|.....:..|.|:::|:|....||.......|
Human   692 GHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEV 756

  Fly   418 PYPQELLRSNWSTSACYLGGRPYFSTNSS-------ARDVQRLAAPLGEKSPGLLFAGDATSLRG 475
            |.|.:...:.|||.........:..|..|       |.|:|..          :.|||:||:...
Human   757 PDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGT----------VFFAGEATNRHF 811

  Fly   476 FGTIDAARSSGIREAQRI 493
            ..|:..|..||:|||.:|
Human   812 PQTVTGAYLSGVREASKI 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10561	NP_476608.1	Amino_oxidase	48..494	CDD:396255	120/498 (24%)
KDM1B	NP_001426046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	282..301
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	447..476		6/31 (19%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	496..507		5/29 (17%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	547..581		3/33 (9%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	573..575		0/1 (0%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	808..824		4/15 (27%)