DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and AAS

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_849999.1	Gene:	AAS / 816553	AraportID:	AT2G20340	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	486	Identity:	202/486 - (41%)
Similarity:	298/486 - (61%)	Gaps:	22/486 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65
            ||:::.||:|...:|:||||.:.|.|..||..|:||||..|||...|:.||....||.|:...|.
plant    12 MDSEQLREYGHLMVDFIADYYKTIEDFPVLSQVQPGYLHKLLPDSAPDHPETLDQVLDDVRAKIL 76

  Fly    66 PGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPA 130
            ||:||||||...||||:::|....:||||::|.|::||||:.|||.||||::|:||:||.|.||.
plant    77 PGVTHWQSPSFFAYYPSNSSVAGFLGEMLSAGLGIVGFSWVTSPAATELEMIVLDWVAKLLNLPE 141

  Fly   131 HFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSNSCI 195
            .|.  |.|.|||||||||||||||.::|||::.:.:..::..|        :||.|||||::|.:
plant   142 QFM--SKGNGGGVIQGSASEAVLVVLIAARDKVLRSVGKNALE--------KLVVYSSDQTHSAL 196

  Fly   196 EKAGVLAAM---PIRLL--PAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIE 255
            :||..:|.:   ..|:|  .:..::.||.::|:.|:..|:.||.||....|.:|||.:.|.|.:.
plant   197 QKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLEAGLIPFFLCANVGTTSSTAVDPLA 261

  Fly   256 SLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDAN 320
            :|..:.....:|.||||||||.|....|......|::..||.|.|.||:.|.|||||.:|::|.:
plant   262 ALGKIANSNGIWFHVDAAYAGSACICPEYRQYIDGVETADSFNMNAHKWFLTNFDCSLLWVKDQD 326

  Fly   321 KVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELA 385
            .:..:.:.:..:||:|....:.:.|::.||||||||||:||:|:..|..|:|.|::::|.||:||
plant   327 SLTLALSTNPEFLKNKASQANLVVDYKDWQIPLGRRFRSLKLWMVLRLYGSETLKSYIRNHIKLA 391

  Fly   386 KQFEQLVLKDSRFELVAPRALGLVCFR--PKGD-----NEITTQLLQRLMDRKKIYMVKAEHAGR 443
            |:|||||.:|..||:|.||...|||||  |..|     |....:||..:....|::|.....:|:
plant   392 KEFEQLVSQDPNFEIVTPRIFALVCFRLVPVKDEEKKCNNRNRELLDAVNSSGKLFMSHTALSGK 456

  Fly   444 QFLRFVVCGMDTKASDIDFAWQEIESQLTDL 474
            ..||..:....|:...:..||:.|:.:.:.|
plant   457 IVLRCAIGAPLTEEKHVKEAWKIIQEEASYL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	172/385 (45%)
AAS	NP_849999.1	PLN02880	3..490	CDD:215475	202/486 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D856958at2759
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.890