DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and hdc

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_005169965.1	Gene:	hdc / 793609	ZFINID:	ZDB-GENE-080102-5	Length:	608	Species:	Danio rerio

Alignment Length:	496	Identity:	214/496 - (43%)
Similarity:	309/496 - (62%)	Gaps:	13/496 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65
            |..:|:...||..::||..||..||:..|:|:|:||::..|||:..|.|||.|..::.|:..:|.
Zfish     1 MQPQEYMLRGKEMVEYIHQYLTGIRERRVVPDVQPGFMRPLLPSSAPYEPEDWSTIMQDVENIIM 65

  Fly    66 PGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPA 130
            ||:.||||||||||:|...|:||::|:|||.....:||:|..||||||||:.|:|||.|.|.||.
Zfish    66 PGVVHWQSPHMHAYFPALNSWPSLLGDMLADAINCLGFTWASSPACTELEMCVLDWLCKALGLPD 130

  Fly   131 HF-QHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRE--SHPELSESEVRGRLVAYSSDQSN 192
            |: .|.....|||::|.:.||..|||:||||:..:...:.  :|.:..||.:..|||||:|||::
Zfish   131 HYLHHHPQSTGGGILQSTVSECTLVALLAARKDRILQMKSEATHTDTDESVLNSRLVAYASDQAH 195

  Fly   193 SCIEKAGVLAAMPIRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIESL 257
            |.:||||:::.:.||.|.....|.|||:||:.|:|||..:|.|||:..||||:||.|::|.::.|
Zfish   196 SSVEKAGLISLVKIRFLQTDAVFSLRGETLQRAVEEDRRSGLIPVMVCATLGSTGVCSFDRLDEL 260

  Fly   258 SAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRV---DSLNFNLHKFMLVNFDCSAMWLRDA 319
            ..||....:||||||||||.|..   |.:||..||.:   ||..||..|:|||:|||:|.|:::.
Zfish   261 GPVCVREGLWLHVDAAYAGSALL---CPELRYFLDGIQFADSFVFNPSKWMLVHFDCTAFWVKNK 322

  Fly   320 NKVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIEL 384
            .|:..:|.||.:||:|.:   |...||.||||||.||||:||:|...|:.|.:.|:.|:|..:|:
Zfish   323 MKLQQTFTVDPLYLRHDN---SNATDFMHWQIPLSRRFRSLKLWFVIRSFGLKKLQEHIRHGVEM 384

  Fly   385 AKQFEQLVLKDSRFELVAPRALGLVCFRPKGDNEITTQLLQRLMDRKKIYMVKAEHAGRQFLRFV 449
            ||.||.||..|:.|::.|.|.||||.|..:..|..|.:||::|....:::::.|....:..|||.
Zfish   385 AKLFESLVRNDTHFQIPAQRHLGLVVFCLRAGNAATQELLRKLTRSGRMFLIPAAVGNQLILRFS 449

  Fly   450 VCGMDTKASDIDFAWQEIESQLTDLQAEQSLVARKSGNVGD 490
            |....|...||...|..|:....:: .:..:|.|:.....|
Zfish   450 VTSQLTTEQDIRRDWSLIQQAAREV-LQSGVVTRQPSVTSD 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	183/384 (48%)
hdc	XP_005169965.1	Pyridoxal_deC	35..414	CDD:278699	183/384 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830