DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amd and Gadl1

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001382689.1	Gene:	Gadl1 / 73748	MGIID:	1920998	Length:	522	Species:	Mus musculus

Alignment Length:	510	Identity:	119/510 - (23%)
Similarity:	201/510 - (39%)	Gaps:	77/510 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KAAIDYIADYLENIRDDDVLPNVE----------PGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65
            ||...::.:....|.::.||...:          |..|..||..||.:..|:...:|.....||
Mouse    44 KAGEKFVEEACRLIMEEVVLKATDVNEKVCEWQPPEQLRQLLDLEMRDTGESQDKLLKLCQDVI- 107

  Fly    66 PGLTHW----QSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFL 126
                |:    ..|...........|.|:...::........:::..||....:|..|   |.|.:
Mouse   108 ----HFSVKTNHPRFFNQLYAGLDYYSLAARIITEALNPSIYTYEVSPVFLLVEEAV---LKKMI 165

  Fly   127 KLPAHFQHASDG---PGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRG--RLVAY 186
            :.....:  .||   |||.|....|..             :|.||.. |::.|..:.|  ||:.:
Mouse   166 ECVGWKE--GDGIFNPGGSVSNMCAMN-------------LARYRHC-PDIKEKGLSGLPRLILF 214

  Fly   187 SSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAIEEDV----AAGRIPVICVA 241
            :|.:.:..::||.       ..|..|...|.      ||..:...:|:.:    ..|.:|.:..|
Mouse   215 TSAECHYSMKKAA-------SFLGIGTQNVYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCA 272

  Fly   242 TLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFML 306
            |.|||...|:|.::.::.|||...:||||||::.|.|....:...|..|:.|.||:.:|.||.::
Mouse   273 TSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLM 337

  Fly   307 VNFDCSAMWLRDANKVVDS-FNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLG 370
            ....|||:.::|.:.::.. ::....||..:.:......|.....|...||..|.|.|:|::.||
Mouse   338 AGIQCSALLVKDKSDLLKKCYSAKATYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALG 402

  Fly   371 AEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGLVCF--RPKGDNE-------------IT 420
            ..||...|.:...|::.....:.|...|:|:.......|||  .|....|             :.
Mouse   403 TSGLEERVNRAFALSRYLVDEIKKREGFKLLMEPEYTNVCFWYIPPSLREMEEGPEFWRKLSLVA 467

  Fly   421 TQLLQRLMDRKKIYMVKAEHAGR-QFLRFVVCGMDTKASDIDFAWQEIESQLTDL 474
            ..:.:::|.:..:.:....|.|: .|.|.||........|:||...||:|...|:
Mouse   468 PAIKEKMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDSLGRDM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	98/400 (25%)
Gadl1	NP_001382689.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810