DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and csad

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_009295318.1	Gene:	csad / 492476	ZFINID:	ZDB-GENE-041114-36	Length:	544	Species:	Danio rerio

Alignment Length:	514	Identity:	119/514 - (23%)
Similarity:	206/514 - (40%)	Gaps:	72/514 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNV----EPGYLLDLLPTEMPEEPEAWKDVLGDIS 61
            ||..:.:.|...|.:.|.:.:.| :..|:...|    :|..|..||..|:.:..|..:.:|..:.
Zfish    63 MDESDGKLFLTEAFNIIMEEILN-KGRDLKEKVCEWKDPDQLRSLLDLELRDHGECHEKLLQRVR 126

  Fly    62 RVIKPGL--THWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAK 124
            .|.|..:  .|   |...........|.::.|.::........:::..:|....:|..|:..|..
Zfish   127 DVAKYSVKTCH---PRFFNQLFAGVDYHALTGRLITETLNTSQYTYEVAPVFVLMEEEVISKLRS 188

  Fly   125 FLKLPAHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRG-----RLV 184
            .:         ....|.|:.....|.:.:.|:..||..|       .|::   :.:|     |:.
Zfish   189 LV---------GWSEGDGIFCPGGSMSNMYAINVARYWA-------FPQV---KTKGLWAAPRMA 234

  Fly   185 AYSSDQSNSCIEKAGVLAAMPIRLLPAGED--FVLRGDTLRGAIEEDVAA--------GRIPVIC 239
            .::|.||:..::|...       .|..|.:  |:::.|.....|.||:.|        ..:|...
Zfish   235 IFTSQQSHYSVKKGAA-------FLGIGTENVFIVQVDESGSMIPEDLEAKIVQAKSQDAVPFFV 292

  Fly   240 VATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKF 304
            .||.|||...|:|.::.::.:||...:|:|||||:.|.....::...|..|::|.:|:.:|.||.
Zfish   293 NATAGTTVQGAFDPLKRIADICERNGMWMHVDAAWGGSVLFSKKHRHLVAGIERANSVTWNPHKM 357

  Fly   305 MLVNFDCSAMWLRD-ANKVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRT 368
            :|....||.:..|| .|.::...:....||..:.:......|.....|..||:...||:|:.::.
Zfish   358 LLTGLQCSVILFRDTTNLLMHCHSAKATYLFQQDKFYDTSLDTGDKSIQCGRKVDCLKLWLMWKA 422

  Fly   369 LGAEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGLVCF-----RPKGD----------NE 418
            :||.||...|.|...|.:...:.:.|...|:||.......|||     ..||.          ::
Zfish   423 IGASGLSQRVDKAFALTRYLVEEMEKRENFQLVCKGPFVNVCFWFIPPSLKGKENSPDYQERLSK 487

  Fly   419 ITTQLLQRLMDRKKI---YMVKAEHAGRQFLRFVVCGMDTKASDIDFAWQEIESQLTDL 474
            :...:.:|:|.|..:   |....||.  .|.|.||........|:||...|:|....||
Zfish   488 VAPVIKERMMKRGTMMVGYQPMDEHV--NFFRMVVVSPQLTTKDMDFFLDEMEKLGKDL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	92/401 (23%)
csad	XP_009295318.1	DOPA_deC_like	140..540	CDD:99743	98/427 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810