DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and Ddc

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	249/478 - (52%)
Similarity:	333/478 - (69%)	Gaps:	3/478 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65
            |:|.||::|.|..:|:||:||||||:..|||.|:||||..|:|...||:||.|:||:.||.|||.
  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100

  Fly    66 PGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPA 130
            ||:|||.||..|||:||:.|||:||.:||:.....|||:||.||||||||||:||||.|.|:|||
  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165

  Fly   131 HFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSNSCI 195
            .|...|.|.|||||||:|||:.|||:|.|:.:.:...:|.|||..|..:.|:||.|.|||::|.:
  Fly   166 EFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSV 230

  Fly   196 EKAGVLAAMPIRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIESLSAV 260
            |:||:|..:.:|.:.: |:..:||..|..|||:|||.|.||...|.|||||.:||:|.::....|
  Fly   231 ERAGLLGGVKLRSVQS-ENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPV 294

  Fly   261 CEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDS 325
            ..:..:|:||||||||.||...|...|.||::..||.|||.||:||||||||||||:|.:.||::
  Fly   295 GNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNA 359

  Fly   326 FNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQ 390
            ||||.:||||..:|.:  ||:|||||||||||||||:|...|..|.|.|:.|:|:|...||||..
  Fly   360 FNVDPLYLKHDMQGSA--PDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGD 422

  Fly   391 LVLKDSRFELVAPRALGLVCFRPKGDNEITTQLLQRLMDRKKIYMVKAEHAGRQFLRFVVCGMDT 455
            |.:.||||||.|...:||||||.||.||....||:|:..|..|::|.|:.....|||..:|...|
  Fly   423 LCVADSRFELAAEINMGLVCFRLKGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFT 487

  Fly   456 KASDIDFAWQEIESQLTDLQAEQ 478
            ::.|::::|:|:.:...:::.||
  Fly   488 QSEDMEYSWKEVSAAADEMEQEQ 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	209/378 (55%)
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	209/378 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11999
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920