Protein Alignment amd and GADL1

DIOPT Version :10

• Sequence 1: NP_476592.1
• Gene: amd / 35188
• FlyBaseID: FBgn0000075
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_997242.2
• Gene: GADL1 / 339896
• HGNCID: 27949
• Length: 521
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 121/531 - (22%)
• Similarity: 204/531 - (38%)
• Gaps: 120/531 - (22%)

  Fly     2 DAKEFREFGKAAIDYIADYLENIRDDDVLPNV----EPGYLLDLLPTEMPE--EP-----EAWKD 55
            |||...:|.:.|...|.:.:. ::..||...|    .|..|..||..||.:  ||     |..:|
Human    41 DAKAGEKFVEEACRLIMEEVV-LKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRD 104

  Fly    56 VLGDISRVIKPGLTHWQSPHMHAYYPTSTSYP-------------SIVGEMLASGFGVIGFSWIC 107
            |:                     :|...|::|             |:|...:........:::..
Human   105 VI---------------------HYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEV 148

  Fly   108 SPACTELEVVVMDWLAKFLKLPAHFQHASDG---PGGGVIQGSASEAVLVAVLAAREQAVANYRE 169
            ||....:|..|:..:.:|:.     ....||   |||.|....|..             :|.|:.
Human   149 SPVFLLVEEAVLKKMIEFIG-----WKEGDGIFNPGGSVSNMYAMN-------------LARYKY 195

  Fly   170 SHPELSESEVRG--RLVAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAI 226
            . |::.|..:.|  ||:.::|.:.:..::||.       ..|..|.:.|.      ||..:...:
Human   196 C-PDIKEKGLSGSPRLILFTSAECHYSMKKAA-------SFLGIGTENVCFVETDGRGKMIPEEL 252

  Fly   227 EEDV----AAGRIPVICVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDL 287
            |:.|    ..|..|.:..||.|||...|:|.::.::.:||...:||||||::.|.|....:...|
Human   253 EKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKL 317

  Fly   288 RKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDS---------FNVDRIYLKHKHEGQSQI 343
            ..|:.|.||:.:|.||.::....|.|:.::|.:.::..         |..|:.|......|..
Human   318 LHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDK-- 380

  Fly   344 PDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGL 408
                  .|...||..|.|.|:|::.||..||...|.:.:.|::.....:.|...|:|:.......
Human   381 ------SIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYAN 439

  Fly   409 VCF---------RPKGD------NEITTQLLQRLMDRKKIYMVKAEHAGR-QFLRFVVCGMDTKA 457
            :||         ..:|.      |.:...:.:|:|.:..:.:....|.|: .|.|.||.......
Human   440 ICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSR 504

  Fly   458 SDIDFAWQEIE 468
            .|:||...||:
Human   505 EDMDFLLDEID 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:395219	97/431 (23%)
GADL1	NP_997242.2	GadA	75..520	CDD:439846	112/496 (23%)