DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment amd and GADL1

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_997242.2	Gene:	GADL1 / 339896	HGNCID:	27949	Length:	521	Species:	Homo sapiens

Alignment Length:	531	Identity:	121/531 - (22%)
Similarity:	204/531 - (38%)	Gaps:	120/531 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DAKEFREFGKAAIDYIADYLENIRDDDVLPNV----EPGYLLDLLPTEMPE--EP-----EAWKD 55
            |||...:|.:.|...|.:.:. ::..||...|    .|..|..||..||.:  ||     |..:|
Human    41 DAKAGEKFVEEACRLIMEEVV-LKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRD 104

  Fly    56 VLGDISRVIKPGLTHWQSPHMHAYYPTSTSYP-------------SIVGEMLASGFGVIGFSWIC 107
            |:                     :|...|::|             |:|...:........:::..
Human   105 VI---------------------HYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEV 148

  Fly   108 SPACTELEVVVMDWLAKFLKLPAHFQHASDG---PGGGVIQGSASEAVLVAVLAAREQAVANYRE 169
            ||....:|..|:..:.:|:.     ....||   |||.|....|..             :|.|:.
Human   149 SPVFLLVEEAVLKKMIEFIG-----WKEGDGIFNPGGSVSNMYAMN-------------LARYKY 195

  Fly   170 SHPELSESEVRG--RLVAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAI 226
            . |::.|..:.|  ||:.::|.:.:..::||.       ..|..|.:.|.      ||..:...:
Human   196 C-PDIKEKGLSGSPRLILFTSAECHYSMKKAA-------SFLGIGTENVCFVETDGRGKMIPEEL 252

  Fly   227 EEDV----AAGRIPVICVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDL 287
            |:.|    ..|..|.:..||.|||...|:|.::.::.:||...:||||||::.|.|....:...|
Human   253 EKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKL 317

  Fly   288 RKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDS---------FNVDRIYLKHKHEGQSQI 343
            ..|:.|.||:.:|.||.::....|.|:.::|.:.::..         |..|:.|......|..
Human   318 LHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDK-- 380

  Fly   344 PDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGL 408
                  .|...||..|.|.|:|::.||..||...|.:.:.|::.....:.|...|:|:.......
Human   381 ------SIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYAN 439

  Fly   409 VCF---------RPKGD------NEITTQLLQRLMDRKKIYMVKAEHAGR-QFLRFVVCGMDTKA 457
            :||         ..:|.      |.:...:.:|:|.:..:.:....|.|: .|.|.||.......
Human   440 ICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSR 504

  Fly   458 SDIDFAWQEIE 468
            .|:||...||:
Human   505 EDMDFLLDEID 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	97/431 (23%)
GADL1	NP_997242.2	AAT_I	77..445	CDD:302748	97/422 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810