DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and GAD1

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000808.2	Gene:	GAD1 / 2571	HGNCID:	4092	Length:	594	Species:	Homo sapiens

Alignment Length:	523	Identity:	133/523 - (25%)
Similarity:	217/523 - (41%)	Gaps:	99/523 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EFGKAAIDYIADYLENI--RDDDVLPNVEPGYLLDLLP---TEMPEEPEAWKDVLGDISRVIKPG 67
            :|....:|.:.:|:...  |...||....|..||:.:.   .|:.:.||:.:.:|.|....:|
Human   115 QFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLK-- 177

  Fly    68 LTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFS--WICSPACTEL---EV----VVMDWLA 123
                        |...|.:|....: |::|..:||.:  |:.|.|.|.:   |:    |:|:.:.
Human   178 ------------YGVRTGHPRFFNQ-LSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQIT 229

  Fly   124 KFLKLPAHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRG-----RL 183
              ||........|...|.|:.....:.:.:.:::|||          :....|.:.:|     :|
Human   230 --LKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAAR----------YKYFPEVKTKGMAAVPKL 282

  Fly   184 VAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAIE----EDVAAGRIPVI 238
            |.::|:||:..|:|||.       .|..|.|.|:      ||..:....|    |....|.:|..
Human   283 VLFTSEQSHYSIKKAGA-------ALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFY 340

  Fly   239 CVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHK 303
            ..||.|||...|:|.|:.::.:||::.:|||||||:.||.....:......|::|.:|:.:|.||
Human   341 VNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHK 405

  Fly   304 FMLVNFDCSAMWLRD------ANKVVDS--FNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRAL 360
            .|.|...|||:.:::      .|::...  |..|:.|......|...|...||..|        .
Human   406 MMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDI--------F 462

  Fly   361 KVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELV---APRALGLVCF-------RPKG 415
            |.|:.::..|..|..|.:.|.:|||:.....:.....||:|   .|.... |||       |...
Human   463 KFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTN-VCFWYIPQSLRGVP 526

  Fly   416 DNEITTQLLQRLMDRKKIYMVKA--EHAGRQ-------FLRFVVCGMDTKASDIDFAWQEIESQL 471
            |:....:.|.::..:.|..|:::  ...|.|       |.|.|:.......|||||..:|||...
Human   527 DSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLG 591

  Fly   472 TDL 474
            .||
Human   592 QDL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	108/423 (26%)
GAD1	NP_000808.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pyridoxal_deC	144..518	CDD:365998	107/416 (26%)
		Substrate binding	190..192		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810