DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and Gad2

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_036695.1	Gene:	Gad2 / 24380	RGDID:	2653	Length:	585	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	127/512 - (24%)
Similarity:	220/512 - (42%)	Gaps:	96/512 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIKPGLTHWQSPHMHA 78
            :.|:....:  |...|:....|..||.....|:.::|:..:::           |||.|:.   .
  Rat   119 LQYVVKSFD--RSTKVIDFHYPNELLQEYNWELADQPQNLEEI-----------LTHCQTT---L 167

  Fly    79 YYPTSTSYPSIVGEMLASGFGVIGFS--WICSPACTE------------LEVVVMDWLAKFLKLP 129
            .|...|.:|....: |::|..::|.:  |:.|.|.|.            ||.|.:..:.:.:..|
  Rat   168 KYAIKTGHPRYFNQ-LSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWP 231

  Fly   130 AHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRG--RLVAYSSDQSN 192
            .       |.|.|:.....:.:.:.|:|.||      |: ..||:.|..:..  ||:|::|:.|:
  Rat   232 G-------GSGDGIFSPGGAISNMYAMLIAR------YK-MFPEVKEKGMAAVPRLIAFTSEHSH 282

  Fly   193 SCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAIEEDV----AAGRIPVICVATLGTTG 247
            ..::|..  ||:.|     |.|.|:      ||..:...:|..:    ..|.:|.:..||.|||.
  Rat   283 FSLKKGA--AALGI-----GTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTV 340

  Fly   248 TCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCS 312
            ..|:|.:.:::.:|:::|:|:|||||:.||.....:......|::|.:|:.:|.||.|.|...||
  Rat   341 YGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLNGVERANSVTWNPHKMMGVPLQCS 405

  Fly   313 AMWLRDAN--KVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLR 375
            |:.:|:..  :..:..:...::.:.||...|.  |.....:..||.....|:|:.:|..|..|..
  Rat   406 ALLVREEGLMQSCNQMHASYLFQQDKHYDLSY--DTGDKALQCGRHVDVFKLWLMWRAKGTTGFE 468

  Fly   376 NHVRKHIELAKQFEQLVLKDSRFELV---APRALGLVCF-------RPKGDNE--------ITTQ 422
            .|:.|.:|||:....::.....:|:|   .|:... |||       |...|||        :...
  Rat   469 AHIDKCLELAEYLYNIIKNREGYEMVFDGKPQHTN-VCFWFVPPSLRVLEDNEERMSRLSKVAPV 532

  Fly   423 LLQRLMDRKKIY---MVKAEHAGRQ--FLRFVVCGMDTKASDIDFAWQEIESQLTDL 474
            :..|:|:    |   ||..:..|.:  |.|.|:........||||..:|||....||
  Rat   533 IKARMME----YGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	103/416 (25%)
Gad2	NP_036695.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Pyridoxal_deC	138..509	CDD:278699	102/409 (25%)
		Substrate binding. /evidence=ECO:0000250	181..183		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810