Protein Alignment amd and hdl-2

DIOPT Version :10

• Sequence 1: NP_476592.1
• Gene: amd / 35188
• FlyBaseID: FBgn0000075
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_501539.3
• Gene: hdl-2 / 182464
• WormBaseID: WBGene00006409
• Length: 611
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 104/510 - (20%)
• Similarity: 192/510 - (37%)
• Gaps: 102/510 - (20%)

  Fly     5 EFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIKPGLT 69
            ||.:.....:.:|.||.:......|:|  |.......:..::||:.|...::|.|:..::.|.:.
 Worm   118 EFIKCMSLVVQFINDYFDESHKQPVIP--ENDVNSSRIHVKVPEKAEELTEILKDLKEIVIPNIC 180

  Fly    70 HWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPAHFQH 134
            |...|..||.: ...|...:|...:::   .:|.....||....:|.::..||:..:.:|.
 Worm   181 HTHHPRYHAKF-AGKSLADLVASTISA---ALGHDVNSSPIIESIERIICKWLSTSMAIPQ---- 237

  Fly   135 ASDGPGGGVIQGSASEA-------------VLVAVLAAREQAVANYRESHPELSESEVRGRLVAY 186
                     |:.|..|.             |.::|:   ..|:..:.::......|: ....:.|
 Worm   238 ---------IKSSLGELRDPIGTVFYTPCDVFISVI---RHAIEKFEKTDSGKERSK-NADYIVY 289

  Fly   187 SSDQSNSCIEKAGVLAAMPIRLLPAGEDFVLRGDTLRGA-----IEEDVAAGRIPVICVATLGTT 246
            .||.|...:::..:...:.:|.:...|.   .|..:..|     :|:|:|.|..|::.:|..|:.
 Worm   290 CSDDSQVPLKEPCISCRVKLRKVITDEK---NGSGMTSANLLKQMEKDIARGFTPLVIIANYGSA 351

  Fly   247 GTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDL-RKGLDRVDSLNFNLHKFMLVNFD 310
            ...|.|:|..|..|....|:|||:||:|||       |..| ....:.|.:|...:|.   |:..
 Worm   352 NIAANDEIWDLVTVSRSKKIWLHLDASYAG-------CEWLDSNSRNNVHALISEVHS---VHIT 406

  Fly   311 CSAMWLRDANKVV----DSFNVDR---IYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRT 368
            ||:::.......|    :...:|.   :|.:|                       .:::||..|.
 Worm   407 CSSLFPYSGRISVVWSCEKLELDGAKILYGEH-----------------------PIRLWILIRL 448

  Fly   369 LGAEGLRNHVRKHIELAKQFEQLVLKDSR-FELVAPRALGLVCF---------RPKGDNEITTQL 423
            .|...:|..|::.|.|...|.:.:...|: ||:......|:..|         |.:..|:||:..
 Worm   449 HGIRSIREAVKRKIILGNAFSERMSHHSQLFEMHHTNEHGVTVFQYKNKKIKDRTEDTNKITSMF 513

  Fly   424 LQRLMDRKKIYMVKAEHAGRQFLRFVV----CG---MDTKASDIDFAWQEIESQL 471
            ...|:....:........|:..::.||    |.   ||...|.:..:..|.|..|
 Worm   514 HNYLVLSSTLKFSIVSFHGKVLIKSVVNYGRCNLSIMDESVSTLVNSVDEFEEAL 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:395219	82/414 (20%)
hdl-2	NP_501539.3	AAT_I	125..527	CDD:450240	92/460 (20%)