Protein Alignment amd and hdl-1

DIOPT Version :10

• Sequence 1: NP_476592.1
• Gene: amd / 35188
• FlyBaseID: FBgn0000075
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_502265.2
• Gene: hdl-1 / 178129
• WormBaseID: WBGene00001839
• Length: 905
• Species: Caenorhabditis elegans
• Alignment Length: 508
• Identity: 164/508 - (32%)
• Similarity: 253/508 - (49%)
• Gaps: 38/508 - (7%)

  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65
            |...:||...|..:||:....|:||.....|.::||||..|||.:.|::.|...|:|.|..::|.
 Worm   343 MSRDQFRNAAKKVVDYLMKQDESIRAARCSPALKPGYLKALLPPKAPQKAEDIDDILEDYHKLIV 407

  Fly    66 PGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPA 130
            |||:|...|:.|::||...|:..::.::|....|..||.|..:||.|||||::||||.:.:.||.
 Worm   408 PGLSHSSHPNFHSFYPAGNSFHCLLADLLGGHIGDAGFYWTSNPALTELEVLMMDWLGEMMALPK 472

  Fly   131 H---FQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSN 192
            .   |..||  .|||.:|.|.:|:..:.::|||...:...::....|..|::..|||||:|..:.
 Worm   473 EFLLFPEAS--RGGGCMQRSDTESNFLVLVAARTDMIRRMKQRDKRLRSSDILARLVAYTSSDAR 535

  Fly   193 SCI--EKAGVLAAMPIRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIE 255
            ..|  :.|..:|.:.:|:||..::|:||||||..||..|:..|.||....|..||:|.|::|.:.
 Worm   536 RSIKMKMAAEVAMVKMRVLPTDQNFILRGDTLHAAIMADIERGLIPFFVGANFGTSGPCSFDHLH 600

  Fly   256 SLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDAN 320
            .|..||.|...||||||||||.|....|...|.:|:|..||......|.::...|...:|:||.:
 Worm   601 ELGPVCREHGTWLHVDAAYAGTALICPEIRGLMRGIDWADSFCTTPSKLIIAVCDVCCLWVRDRH 665

  Fly   321 KVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELA 385
            |:             :|......||.....:|..:|..|||:|...|:.|.|.|:|.:|:||.|.
 Worm   666 KL-------------QHASLENHPDLPFKGLPTSQRVGALKIWFMIRSFGVENLQNQIREHIRLG 717

  Fly   386 KQFEQLVLKDSRFELVAPRALGLVCFRPKGDNEITTQLLQRLMDRKKIYMVKAEHAGRQFLRFVV 450
            :...:::.||.|||:.....:||:|||.|.::.....||.|..:...:.:.......:..:|..:
 Worm   718 QVMTKILQKDLRFEVCNKVVMGLICFRAKSNDMFNKALLYRCNETGNVSLASCVLQNKFVIRMCI 782

  Fly   451 CGMDTKASDIDFAWQEIESQLTDLQAEQSLVARKSGNVGDLAQHFQIHLSTEN 503
            ........|:|.|::.|                  .|..|:.:.||..:...|
 Worm   783 NSPKCSEEDLDSAYKLI------------------CNEYDILKPFQYRIEVMN 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:395219	140/383 (37%)
hdl-1	NP_502265.2	Pyridoxal_deC	377..746	CDD:395219	140/383 (37%)