Protein Alignment amd and unc-25

DIOPT Version :10

• Sequence 1: NP_476592.1
• Gene: amd / 35188
• FlyBaseID: FBgn0000075
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_499689.1
• Gene: unc-25 / 176713
• WormBaseID: WBGene00006762
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 118/480 - (24%)
• Similarity: 201/480 - (41%)
• Gaps: 48/480 - (10%)

  Fly    14 IDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIKPGLTHWQSPHMHA 78
            :.||.|  :|.||..:|....|..:..|:...:||:||:...::.....|::.|:   ::.|...
 Worm    43 LKYIKD--QNDRDQKILEFHHPDKMQMLMDLSIPEKPESLLKLVKSCEDVLRLGV---RTGHPRF 102

  Fly    79 YYPTSTSYP--SIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPAHFQHASDG--- 138
            :...|....  |:.||.|.:......|::..:|....:|..||   |:..:........:||
 Worm   103 FNQISCGLDLVSMAGEWLTATANTNMFTYEIAPVFILMEKSVM---ARMWEAVGWDPEKADGIFA 164

  Fly   139 PGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSNSCIEKAGVLAA 203
            |||.:       |.|.|:.|||.|...  |..|..:.:...   |..::|:.|:..|:.|..:..
 Worm   165 PGGAI-------ANLYAMNAARHQLWP--RSKHLGMKDIPT---LCCFTSEDSHYSIKSASAVLG 217

  Fly   204 MPIRL---LPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIESLSAVCEEFK 265
            :....   :|..::..:..:.|...|.|....|..|.....|.|:|...|:|.:|.::.:||..|
 Worm   218 IGADYCFNIPTDKNGKMIPEALEAKIIECKKEGLTPFFACCTAGSTVYGAFDPLERVANICERHK 282

  Fly   266 VWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDSFNVDR 330
            :|.|||||:.||.....|......|::|.:|:.:|.||.|.....|||...|....:.....:..
 Worm   283 LWFHVDAAWGGGMLLSPEHRYKLAGIERANSVTWNPHKLMGALLQCSACLFRQDGLLFQCNQMSA 347

  Fly   331 IYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKD 395
            .||..:.:......|.....|..||.....|:|:.:::.|.||.|..:.|.::||..|.:.:.:.
 Worm   348 DYLFQQDKPYDVSFDTGDKAIQCGRHNDVFKLWLMWKSKGMEGYRQQINKLMDLANYFTRRIKET 412

  Fly   396 SRFELVA--PRALGLVCF-------RPKGDNEITTQLLQRLMDRKKIYMVK--AEHAGRQ----- 444
            ..|||:.  |..|. :||       |.....|:..: |:::..:.|..|::  ....|.|
 Worm   413 EGFELIIENPEFLN-ICFWYVPSKIRNLEPAEMRAR-LEKIAPKIKAGMMQRGTTMVGYQPDKQR 475

  Fly   445 --FLRFVVCGMDTKASDIDFAWQEI 467
              |.|.::........|:||..:||
 Worm   476 PNFFRMIISNQAITREDLDFLIKEI 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:395219	98/395 (25%)
unc-25	NP_499689.1	DOPA_deC_like	102..503	CDD:99743	102/416 (25%)