Protein Alignment amd and tdc-1

DIOPT Version :10

• Sequence 1: NP_476592.1
• Gene: amd / 35188
• FlyBaseID: FBgn0000075
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_495743.1
• Gene: tdc-1 / 174327
• WormBaseID: WBGene00006562
• Length: 705
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 222/539 - (41%)
• Similarity: 320/539 - (59%)
• Gaps: 33/539 - (6%)

  Fly     1 MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIK 65
            |...|||::||..:|||.||||||:...|:|.:|||||.||:|:|.|..||:::.|:.|..::|.
 Worm    77 MTRDEFRQYGKETVDYIVDYLENIQKRRVVPAIEPGYLKDLIPSEAPNTPESFESVMEDFEKLIM 141

  Fly    66 PGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPA 130
            ||:||||.|..|||:|...|:|||:.:||:...|.:||||...||.||||::::||..|.:.|||
 Worm   142 PGITHWQHPRFHAYFPAGNSFPSIIADMLSDAIGCVGFSWAACPAMTELELIMLDWFGKMIGLPA 206

  Fly   131 HFQHASD-GPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSNSC 194
            .|...:: |.||||||.||||...|.:||||.:.:...|:..|.:.|..:..:|:||.|.:::|.
 Worm   207 EFLPLTENGKGGGVIQSSASECNFVTLLAARFEVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSS 271

  Fly   195 IEKAGVLAAMPIRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIESLSA 259
            :|||.::..:.:|:|.....|.|||||||.||:||...|.||.....|||||..|::|.:..:..
 Worm   272 VEKACMIGMVKLRILETDSKFRLRGDTLRNAIQEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGP 336

  Fly   260 VCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVD 324
            :|:|.::||||||||:|.||...|...|..|::...|.|.|.:|::|:|||||.||:||..|:..
 Worm   337 ICKENELWLHVDAAYSGSAFICPEFRPLMNGIEYAMSFNTNPNKWLLINFDCSTMWVRDRFKLTQ 401

  Fly   325 SFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFE 389
            :..||.:||:|....:|  .|:|||.|||.||||:||:|...|..|.:||:.::|:|:.|||:.|
 Worm   402 ALVVDPLYLQHSWMDKS--IDYRHWGIPLSRRFRSLKLWFVIRMYGIDGLQKYIREHVRLAKKME 464

  Fly   390 QLVLKDSRFELVAPRALGLVCFRPKGDNEITTQLLQRLMDRKKIYMVKAEHAGRQFLRFVVCGMD 454
            .|:..|::||:|....:||||||.|||:|:...||.||....:|:||.|....|..:||.||..:
 Worm   465 TLLRADAKFEIVNEVIMGLVCFRMKGDDELNQTLLTRLNASGRIHMVPASLGDRFVIRFCVCAEN 529

  Fly   455 TKASDIDFAWQ--------------------------EIESQLTDLQ----AEQSLVARKSGNVG 489
            ....||:.|::                          .:|..:.||.    .|:.|..:.|.|..
 Worm   530 ATDKDIEVAYEIIAQATQHVLHDSVKAVIAEEDEEAVALEEMVADLNITETPEKCLTRQNSANAA 594

  Fly   490 DLAQHFQIHLSTENATHEK 508
            :..|..:..||.|....:|
 Worm   595 ESGQKLERQLSKEEILAQK 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:395219	172/379 (45%)
tdc-1	NP_495743.1	Pyridoxal_deC	111..489	CDD:395219	172/379 (45%)